The ONE – the daily Longevity Complex from MoleQlar – was developed in collaboration with many experts. The formula contains everything that makes MoleQlar special: Longevity-Innovation spirit, current science, superior qualityOne sachet a day provides you with these 13 high-quality longevity molecules:
Calcium alpha-ketoglutarate, trans-resveratrol, luteolin, quercetin, glycine, theanine, hyaluronic acid, glucosamine, inositol, creatine, magnesium taurate, L-citrulline malate and vitamin C
Why exactly these 13? There are now many health drinks with overwhelming compositions. True to the motto the more ingredients the better, the individual molecules are usually contained in very low concentrations that have not been tested for their effects in studies. The approach with MoleQlar ONE was different. We have studied a variety of molecules and evaluated them for their potential to promote longevityIt was particularly important to us that the dosages used were based on scientific evidence.
What is aging?
Aging is extremely complex. Everything we see and feel in terms of signs of aging is only the end point of molecular processes that often no longer function properly over years and decadesIf we feel less efficient over time and are more easily exhausted, then we have probably been suffering from a so-called mitochondrial dysfunctionIf we forget things more quickly or age pigments become visible in the skin, then there is a loss of proteostasis before. All this does not happen overnight – it develops gradually on a molecular level and at a different pace for each person.
In addition to the two mentioned, there are ten other signs of aging - twelve in total. A team led by scientist Carlos Lopez Otin discovered and defined these signs. This "Hallmarks of Aging“ are the basis of all age-related diseases and changesIf we could reverse these characteristics, the researchers hypothesize, we would age more slowly or not at all. However, research is not yet advanced enough to achieve the latter.
To help you better understand which processes accelerate aging and how the different molecules of the MoleQlar ONE complex affect your body, we will give you a brief overview:
Calcium alphaketoglutarate (AKG)
Alpha-ketoglutarate (AKG) is a cumbersome name for an important enzyme in the citric acid cycle. You may remember this metabolic pathway from biology class. It takes place in our cell power plants (mitochondria) and helps you to produce enough energy every day in the form of ATP to produce. However, between the ages of 40 and 80, the body’s AKG reserves decrease by a factor of 10. (R) The result is a stuttering energy supply. This is exactly where CaAKG comes in by boosting your energy metabolism. However, AKG is not contained in food, which is why we have to rely on supplements, for exampleThe combination with calcium ensures that AKG is absorbed more efficiently in the intestine.
AKG study situation:
In human studies, AKG was able to support muscle and bone development (R, R). In animal studies the organisms studied lived up to 50% longer. (R) Larger studies on humans are still ongoing, but initial data have shown a reduction in biological age by several years. (R) In addition to general support of your energy metabolism, AKG is also particularly valuable for your intestinal cells, which means that the molecule indirectly contributes to an improved microbiome. By converting pro-collagen into collagen, alpha-ketoglutarate can also support wound healing. (R)
CaAKG plays a role here: energy metabolism, bone metabolism, immune system, microbiome
Hallmarks of Aging: CaAKG affects the following Hallmarks of Aging:
- mitochondrial dysfunction
- Epigenetic changes
- stem cell exhaustion
- Inflammaging – inflammatory aging
- microbiome dysbiosis
Trans-Resveratrol
Maybe you have heard of the French paradox? Despite lots of meat, cheese and wine the French live longer on average. The longevity researchers around Professor David Sinclair think they have found the key to this puzzle: resveratrolThis polyphenol, which is found mainly in the skin of red grapes, seems to be responsible for the French paradox. For plants, resveratrol is a natural defense against harsh environmental conditions and pathogens. In humans, resveratrol is a potent activator of various longevity pathwaysThe trans-resveratrol form has been shown in studies to be more stable and better bioavailable.
Resveratrol study situation:
Longevity pathways influenced by resveratrol include the sirtuins and the AMPK. (R, R) Sirtuins, also known as longevity genes, are considered one of the most promising approaches in longevity research. (R)
Furthermore, resveratrol leads to a activation of the transcription factor Nrf2, to improved cell resistance to oxidative stress. (R) The polyphenol in grapes combines a whole range of desirable effects. In several studies, resveratrol has extended the life of fruit flies and mice.The researchers found that the activity of sirtuins was influenced by NAD dependent. (R,R)
This is where trans-resveratrol plays a role: energy metabolism, immune system, microbiome, epigenetics
Hallmarks of Aging:
- mitochondrial dysfunction
- Genomic instability
- Epigenetic changes
- telomere shortening
- Deregulated nutrient measurement
- Prevented macroautophagy
- Inflammaging – Inflammation Aging
- microbiome dysbiosis
luteolin
The molecule belongs to the family of flavonoids and occurs naturally in olive oil, rosemary and thyme.
Luteolin study situation:
Similar to resveratrol, it can activate the longevity genes, the so-called sirtuins. (R) According to studies, luteolin can also help the body to eliminate defective cells more effectively. The molecule does this by inhibiting the nuclear factor kappa-B (NF-kB). (R) NF-kB is one of the signaling pathways that becomes unbalanced with age. Too high NF-kB levels lead to a so-called Inflammaging, an excessive inflammatory response in old age that occurs throughout the body.
Another positive effect of luteolin: The flavonoid supports the recycling of NAD, one of your most important enzymes in energy metabolismLuteolin stimulates the key enzyme NAMPT, which converts NAM into NMN. This is the rate-limiting step in the so-called salvage pathway. (R)
This is where luteolin plays a role: immune system, epigenetics
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Cellular senescence
- Altered intercellular communication
- epigenetic change
quercetin
quercetin found in the peels of apples and makes them taste bitter. Professor James L. Kirkland from the renowned Mayo Clinic was one of the first to discover the potential of quercetin.(R)
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Cellular senescence
- Altered intercellular communication
- epigenetic change
- loss of proteostasis
- mitochondrial dysfunction
- Dysregulated Nutrient Measurement & Fasting
- Prevented macroautophagy
- microbiome dysbiosis
L-glycine
Glycine is a non-essential amino acid that is involved in countless metabolic processes in your body. It is a component of collagen, a structural protein that you find in the skin, bones and tendons. Glycine is also part of the structural formula of glutathioneThis molecule is one of the most important for the elimination of free radicals. As we age, glutathione levels decrease, which can lead to more cell damage. (R)
Glycine study situation:
In animal experiments, glycine prolong life in both mice and worms. (R,R) Clinical studies have already shown that taking glycine can reduce long-term blood sugar (HbA1c) in diabetics and that blood pressure in hypertensive patients decreased after three months of taking it. (R,R)
In the form of GlyNAC could also be shown to people, that glycine can influence various hallmarks of aging in humans, including mitochondrial dysfunction and genomic instability. (R) Further applications are under research, but glycine has already been given the name “Geroprotector“ Loosely translated, this means something like: protector of the elderly.
This is where L-glycine plays a role: immune system, microbiome, epigenetics, energy metabolism, skin and bone metabolism
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- epigenetic change
- loss of proteostasis
- mitochondrial dysfunction
- Dysregulated Nutrient Measurement & Fasting
- Prevented macroautophagy
- microbiome dysbiosis
- stem cell exhaustion
theanine
In Asian culture, the health-promoting properties of green tea known and research is slowly uncovering the molecules behind it. Firstly, there is the complicated-sounding epigallocatechin gallate (EGCG), which supports your NAD metabolism. The hot drink also supports your metabolic health by regulating blood sugar levels.(R,R)
Theanine study situation:
The amino acid theanine in green tea increases your concentration and if you have drunk too much coffee, theanine can compensate for this. It has long been known that tea has a calming effect on the body and mind This effect seems to come mainly from theanine. (R)
But these are by no means all the benefits of this molecule. In this randomized study (R), regular intake of theanine could lead to reduction of colds lead.
This is where theanine plays a role: immune system, energy metabolism
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Altered intercellular communication
- Epigenetic changes
- Dysregulated Nutrient Measurement & Fasting
- microbiome dysbiosis
hyaluronic acid
Hyaluron is known as a “wrinkle filler” in the cosmetics industry. Due to its water-binding properties Hyaluron supports our largest organ, the skin, against premature aging. In old age our hyaluronic acid content is steadily decreasing. A 75-year-old person has about only a quarter of the hyaluronic acid content in the skin as a 19-year-old comparison person. (R)
Hyaluron study situation:
Hyaluron as a supplement was tested in this randomized study, among others. (R). The result: 60 test subjects were able to achieve a reduction in their hyaluronic acid levels after just 28 days of regular intake.The depth of wrinkles was reduced and the skin was on average 10.6% better hydrated.
In addition to the skin, we also find hyaluronic acid in cartilage. Here, around 5g of hyaluronic acid is synthesized and broken down again every day. So it is no wonder that as a “lubricant” is essential for our jointsIn a Japanese study, 60 subjects with knee osteoarthritis were treated with hyaluronic acid for a whole year, with symptoms improving as a result of the treatment. (R)
Due to his anti-inflammatory properties and its ubiquitous occurrence in the body, hyaluronic acid is also being researched in the therapy of other diseases. (R)
This is where hyaluronic acid plays a role: immune system, skin, bone and cartilage metabolism
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Altered intercellular communication
- stem cell exhaustion
- Altered macroautophagy
glucosamine
Our body needs glucosamine when it wants to combine carbohydrates with fats or proteins to produce new molecules.Particularly This molecule is often found in joints and connective tissue, which is why it is also taken for joint pain in practice. In the form of glucosamine sulfate, the body can demonstrably absorb glucosamine. The scientists were able to detect increased levels of glucosamine in both the blood and the synovial fluid after taking glucosamine sulfate. (R,R)
Glucosamine study situation:
In two randomized trials (R,R) was able to reduce the Taking glucosaminosulfate slows down cartilage degradation and relieves symptomsGlucosamine appears to reduce inflammatory signaling proteins such as interleukin 1. (R)
New research also shows a longevity effect of glucosamine, in which autophagy, the cell's own recycling system, is increased. Furthermore, glucosaminosulfate has a anti-inflammatory effect on the downregulation of nuclear factor kappa-B (NF-kB). The researchers suspect that this is one of the reasons for the positive effect of glucosaminosulfate on longevity. (R,R)
This is where glucosamine sulfate plays a role: immune system, sugar and cartilage metabolism
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Altered intercellular communication
- Prevented macroautophagy
- mitochondrial dysfunction
- loss of proteostasis
- Genomic instability
inositol
This vitamin-like molecule supports your sugar and fat metabolism. As a substance produced by the body, inositol is found primarily in cell membranes, for example in the liver, kidneys or brain. Inositol is either produced by the body itself or obtained from plant foods, such as grapefruit juice, recorded. (R,R)
Inositol study situation:
In a large meta-analysis, several studies on women with polycystic ovary syndrome (PCO) and inositol were summarized. By taking Not only did their insulin sensitivity improve, the researchers also found improved fertility. (R)
Inositol substitution can also be beneficial in other diseases, such as non-alcoholic fatty liver disease (NAFLD). (R) In patients with hypothyroidism, a Combined intake of selenium and inositol lowers the hormone TSH and reduces antibodies against the thyroid. This alleviated the symptoms of hypothyroidism. (R)
With this broad range of applications and the many clinical research studies, inositol is a promising molecule for the future.
This is where inositol plays a role: immune system, sugar and fat metabolism and hormone balance
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Altered intercellular communication
- mitochondrial dysfunction
- loss of proteostasis
creatine monohydrate
Creatine is an essential. With the help of this molecule the muscle's own ATP reserves can be increased, which is noticeable as increased strength. As we age, our body's own creatine production decreases, which is why it also makes sense for non-athletes to take creatine. (R) From the age of 50, muscle mass decreases by 1-2% per year, and muscle strength even decreases by 1-5%. (R,R,R) We can compensate for this for a long time, but at some point the muscles are so weak that even previously simple things, such as climbing stairs, become more difficult. For this reason, Strength training in combination with creatine is an effective approach to maintaining muscle strength in old age.
Creatine study situation:
In addition to its strength-enhancing effect Creatine dampens inflammatory processes in the body and supports your immune system. (R) In addition, creatine leads to improved cognitive performance and offered protection against neurodegenerative diseases in animal studies, in which it promoted the elimination of lipofuscin in the brain, also known as “age pigment.” (R)
Creatine also appears to have a positive effect on depression. In a randomized, double-blind study (corresponding to the highest standard of science), creatine supported the absorption and effect of SSRIs, a group of antidepressants. (R)
This is where creatine plays a role: immune system, muscle and bone metabolism, cognitive performance
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- Altered intercellular communication
- mitochondrial dysfunction
- loss of proteostasis
magnesium taurate
magnesium is that eighth most common element in the Earth's crust and occurs in various chemically bound forms. In our body Magnesium is involved as a co-factor in more than 300 enzymes, which have a wide variety of functions in the body. From the Protein biosynthesis, via muscle and nerve signals to the regulation of blood sugar and blood pressure.(R) According to the National Consumption Study II of the Federal Ministry of Food, Agriculture and Consumer Protection a large proportion of people consume too little magnesium. (R)
Magnesium study situation:
A magnesium deficiency is associated with some important “age-related diseases”, such as arteriosclerosis, elevated blood lipid levels, Alzheimer’s disease and type 2 diabetes mellitus. (R) The functions of magnesium in the body are diverse, as shown by the number of enzymes in which magnesium is involved. In addition, it helps stabilize the genome and thereby reduces DNA damage. (R,R)
The organic compound of the amino acid taurine with magnesium also ensures improved bioavailability and additionally functions Taurine also acts as a mediator for healthy mitochondria. (R,R) Magnesium reduces tiredness and exhaustion, promotes your energy metabolism and calms the nerves.
Here plays magnesium taurate a role: immune system, muscle metabolism, cognitive performance, sleep, energy metabolism, cardiovascular health, insulin sensitivity
Hallmarks of Aging:
- Inflammaging – Inflammation Aging
- mitochondrial dysfunction
- Genomic instability
- telemural abrasion
- Deregulated nutrient measurement
citrulline malate
The amino acid L-citrulline comes naturally occurring in watermelon and is involved, for example, in the urea cycle in the liver and kidney. L-citrulline leads to improved nitric oxide (NO) production in the body. To achieve this effect, however, you would have to consume at least 1-1.5kg of watermelons – per day! (R)
Malate is the salt of malic acid and is found in the body, among other things, in the citric acid cycle. Just like alpha-ketoglutarate.
Citrulline study situation:
Nitric oxide (NO) is needed by our blood vessels to expand (vasodilation). As we age, our cardiovascular health tends to deteriorate, NO levels drop and blood pressure rises. (R) For this reason, it can be beneficial to increase the body's own NO production again. L-arginine and L-citrulline are generally suitable for this, as both are involved in nitrogen metabolism. Although L-arginine is the direct precursor of NO, supplementing L-arginine is not effective and leads to more side effects. L-citrulline in combination with malate is better absorbed and is more effective in increasing NO synthesis. (R,R)
The increased NO production also benefits your muscles. They can generate more power through the increased blood flow. (R)
Malate has been shown to improve lifespan and mitochondrial function in animal studies. (R,R). As part of the citric acid cycle, malate is involved in the production of energy in the form of ATP. Supplementation in mice showed increased energy production. (R)
This is where L-citrulline malate plays a role: energy metabolism, cardiovascular system
Hallmarks of Aging:
- mitochondrial dysfunction
- Dysregulated Nutrient Measurement & Fasting
Vitamin C (ascorbic acid)
Our body can vitamin C not produce it yourself, which is why we depend on our food. If we do not do this sufficiently, we can become seriously ill. In the past, sailors in particular often suffered from a vitamin C deficiency due to a lack of fresh fruit, which manifested itself in the disease scurvy has manifested. (R,R)
Vitamin C has many roles in the body. It contributes to normal immune function, supports energy balance, helps with muscle recovery, is involved in collagen formation for skin and bones and protects you from infections. (R,R,R)
Vitamin C study situation:
Vitamin C as a single molecule is not associated with greater longevity - at least there are no studies on this (yet). However, it does have some synergistic effects, especially with alpha-ketoglutarate. In addition, vitamin C is being researched as an additive in the treatment of cancer (R) and it helps to shorten the duration of colds. (R)
This is where vitamin C plays a role: energy metabolism, immune system
Hallmarks of Aging:
- Genomic instability
- telomere shortening
- loss of protostasis
- Cellular senescence
- mitochondrial dysfunction
- epigenetic change
- altered intercellular communication
