The ONE - MoleQlar's daily longevity complex - was developed in collaboration with many experts. The formulation contains everything that defines MoleQlar: Longevity innovative spirit, current science, outstanding quality. One sachet a day provides you with these 13 high-quality longevity molecules:
Calcium alphaketoglutarate, trans-resveratrol, luteolin, quercetin, glycine, theanine, hyaluronic acid, glucosamine, inositol, creatine, magnesium taurate, L-citrulline malate and vitamin C
Why exactly these 13? There are now many health drinks with overwhelming compositions. True to the motto the more ingredients the better, the individual molecules are usually contained in very low concentrations and their effects have not been tested in studies. With MoleQlar ONE the approach was different. We examined a variety of molecules and evaluated them for their potential to promote longevity. It was particularly important to us that the dosages used were based on scientific evidence.
What is aging?
Aging is extremely complex. Everything we see and feel in terms of signs of aging is just the end point of molecular processes that often no longer function properly for years and decades. If we feel less efficient over time and are exhausted more quickly, a so-called mitochondrial dysfunction has probably existed for some time. If we forget things more quickly or if age pigments become visible in the skin, then there is a loss of proteostasis . All of this doesn't happen overnight - it develops gradually on a molecular level and at different rates for all people.
In addition to the two mentioned, there are ten other signs of aging - twelve in total. A team led by scientist Carlos Lopez Otin discovered and defined these characteristics. These “Hallmarks of Aging” underlie all age-related diseases and changes. If we could reverse these characteristics, the researchers hypothesize, we would age more slowly or even not at all. However, research is not yet advanced enough for the latter.
So that you can better understand which processes accelerate aging and how the different molecules in the MoleQlar ONE complex affect your body, we will give you a brief overview:
Calcium alphaketoglutarate (AKG)
Alphaketoglutarate (AKG) is a cumbersome name for an important enzyme in the citrate cycle. Maybe you remember this metabolic pathway from biology class. It takes place in our cell power plants (mitochondria) and helps you to produce enough energy every day in the form of ATP . Between the 40th and 80. However, with age, the body's reserves of AKG decrease by a factor of 10. (R) The result of this is stuttering energy supply. This is exactly where CaAKG comes in by boosting your energy metabolism. However, there is no AKG in food, which is why we rely on supplements, for example. The connection with calcium ensures that AKG is absorbed more efficiently in the intestine.
AKG study situation:
In human studies, AKG was able to support muscle and bone development (R, R). In animal studies the organisms examined sometimes lived up to 50% longer. (R) Larger studies on humans are still ongoing, but initial data have shown a reduction in biological age by several years. (R) In addition to general support for your energy metabolism, AKG is also particularly valuable for your intestinal cells, whereby the molecule indirectly contributes to an improved microbiome. By converting pro-collagen into collagen, alphaketoglutarate can also support your body in wound healing. (R)
CaAKG plays a role here: energy metabolism, bone metabolism, immune system, microbiome
Hallmarks of Aging: CaAKG affects the following Hallmarks of Aging:
- Mitochondrial dysfunction
- Epigenetic changes
- Stem cell depletion
- Inflammaging – inflammatory aging
- Microbiome dysbiosis
Trans-Resveratrol
Perhaps you have heard of the French paradox? Despite lots of meat, cheese and wine The French live longer on average. The longevity researchers around Professor David Sinclair think they have found the key to this puzzle: Resveratrol. This polyphenol, which is mainly found in the skin of red grapes, seems to be responsible for the French paradox. For plants, resveratrol is a natural defense against harsh environmental conditions and pathogens. In humans, resveratrol is a potent activator of various longevity pathways at the molecular level. The trans-resveratrol form has been shown in studies to be more stable and more bioavailable.
Resveratrol study situation:
The longevity pathways influenced by resveratrol include the sirtuins and the AMPK. (R, R) Sirtuins in particular, which are also known as longevity genes, are considered one of the most promising approaches in longevity research. (R)
Furthermore, resveratrol leads to improved cell resistance to oxidative stress via activation of the transcription factor Nrf2. (R) The polyphenol from the grape combines a whole range of desirable effects. Resveratrol has been shown to extend the lives of fruit flies and mice in several studies. The researchers found that the activity of the sirtuins is dependent, among other things, on NAD . (R,R)
Trans-resveratrol plays a role here: energy metabolism, immune system, microbiome, epigenetics
Hallmarks of Aging:
- Mitochondrial dysfunction
- Genomic instability
- Epigenetic changes
- Telomere shortening
- Deregulated nutrient measurement
- Prevented macroautophagy
- Inflammaging – inflammatory aging
- Microbiome dysbiosis
Luteolin
The molecule belongs to the family of flavonoids and occurs naturally in olive oil, rosemary and thyme.
Luteolin study situation:
Similar to resveratrol, it can activate longevity genes, the so-called sirtuins. (R) According to studies, luteolin can also help the body better eliminate faulty cells. The molecule achieves this by inhibiting the nuclear factor kappa-B (NF-kB). (R) NF-kB is one of the signaling pathways that become unbalanced with age. NF-kB levels that are too high lead to so-called Inflammaging, an excessive inflammatory reaction in old age that takes place throughout the entire body.
Another positive effect of luteolin: The flavonoid supports the recycling of NAD, one of your most important enzymes in energy metabolism. Luteolin stimulates the key enzyme NAMPT, which converts NAM into NMN. This is the rate-determining step in the so-called Salvage Pathway. (R)
Luteolin plays a role here: Immune system, epigenetics
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Cellular senescence
- Altered intercellular communication
- Epigenetic change
Quercetin
Quercetin is found in the peels of apples and makes them taste bitter. Professor James L. Kirkland, from the renowned Mayo Clinic, was one of the first to discover the potential of quercetin. (R)
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Cellular senescence
- Altered intercellular communication
- Epigenetic change
- Loss of proteostasis
- Mitochondrial dysfunction
- Dysregulated nutrient measurement & fasting
- Prevented macroautophagy
- Microbiome dysbiosis
L-Glycine
Glycine is a non-essential amino acid that is involved in countless metabolic processes in your body. It is a component of collagen, a structural protein that you find in the skin, bones and tendons. Glycine is also part of the structural formula of Glutathione. This molecule is one of the most important for the elimination of free radicals. As we age, glutathione levels decrease, which can lead to more cell damage. (R)
Glycine study situation:
In animal experiments, glycine was able to extend life in both mice and worms. (R,R) In clinical studies it has already been shown that taking glycine could reduce long-term sugar (HbA1c) in diabetics and that after three months of taking it, blood pressure in hypertension patients sank. (R,R)
In the form of GlyNAC it has also been shown in humans that glycine has a wide variety of properties Hallmarks of aging in humans can influence, including mitochondrial dysfunction and genomic instability. (R) Further areas of application are in research, but glycine has already been given the name “Geroprotector”. Loosely translated, this means something like: age protector.
L-glycine plays a role here: Immune system, microbiome, epigenetics, energy metabolism, skin and bone metabolism
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Epigenetic change
- Loss of proteostasis
- Mitochondrial dysfunction
- Dysregulated nutrient measurement & fasting
- Prevented macroautophagy
- Microbiome dysbiosis
- Stem cell depletion
Theanine
The health-promoting properties of green tea have been known for a long time in Asian culture and so slowly research uncovers the molecules behind it. On the one hand, there is the complicated-sounding Epigallocatechin gallate (EGCG), which supports your NAD metabolism. The hot drink also supports your metabolic health by regulating blood sugar levels. (R,R)
Theanine study situation:
The amino acid theanine in green tea increases your concentration and if you have drunk too much coffee, theanine can compensate for this. It has long been known that tea has a calming effect on the body and mind . This effect appears to come primarily from theanine. (R)
But these are by no means all the advantages of this molecule. In this randomized study (R), regular intake of theanine could lead to a reduction in colds .
Theanine plays a role here: Immune system, energy metabolism
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Altered intercellular communication
- Epigenetic changes
- Dysregulated nutrient measurement & fasting
- Microbiome dysbiosis
Hyaluronic acid
Hyaluron is known as a “wrinkle filler” in the cosmetic industry. Thanks to its water-binding properties hyaluronic acid supports our largest organ, the skin, against premature aging. As we age our hyaluronic content steadily decreases. A 75-year-old person only has a quarter of the hyaluronic content in their skin as a 19-year-old comparison person. (R)
Hyaluron study situation:
Hyaluron as a supplement was tested, among other things, in this randomized study. (R). The result: In 60 test subjects, after just 28 days of regular intake of hyaluronic acid, the depth of wrinkles was reduced and the skin was on average 10.6% better hydrated.
In addition to the skin, we also find hyaluronic acid in cartilage. Around 5g of hyaluronic acid is synthesized and broken down here every day. No wonder then that it is essential as a “lubricant” for our joints. In a Japanese study, 60 test subjects with knee osteoarthritis were treated with hyaluronic acid for an entire year, with symptoms improving as a result of the treatment. (R)
Due to its anti-inflammatory properties and its ubiquitous presence in the body, hyaluronic acid is also being researched in the therapy of other diseases. (R)
Hyaluronic acid plays a role here: Immune system, skin, bone and cartilage metabolism
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Altered intercellular communication
- Stem cell depletion
- Altered macroautophagy
Glucosamine
Our body needs glucosamine when it wants to combine carbohydrates with fats or proteins to produce new molecules. This molecule is particularly common in joints and connective tissue , which is why it is also taken in practice for joint pain. It has been proven that the body can absorb glucosamine in the form of glucosamine sulfate. The scientists were able to detect increased levels of glucosamine in both the blood and the synovial fluid after taking glucosamine sulfate. (R,R)
Glucosamine study situation:
In two randomized studies (R,R), taking glucosaminosulfate was able to slow down the breakdown of cartilage and reduce symptoms in people with osteoarthritis of the knee alleviate. Glucosamine appears to reduce inflammatory signaling proteins such as interleukin 1. (R)
New research also shows a longevity effect of glucosamine, in which autophagy, the cell's own recycling system, is increased. Furthermore, glucosamine sulfate has an anti-inflammatory effect via the downregulation of nuclear factor kappa-B (NF-kB). The researchers also suspect that this is one of the reasons for the positive effect of glucosaminosulfate on longevity. (R,R)
Glucosamine sulfate plays a role here: Immune system, sugar and cartilage metabolism
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Altered intercellular communication
- Prevented macroautophagy
- Mitochondrial dysfunction
- Loss of proteostasis
- Genomic instability
Inositol
This vitamin-like molecule supports your sugar and fat metabolism. As an endogenous substance, inositol is found primarily in cell membranes, for example in the liver, kidneys or brain. Inositol is either produced by the body itself or absorbed through plant foods, such as Grapefruit juice. (R,R)
Inositol study situation:
A large meta-analysis summarized several studies on women with polycystic ovarian syndrome (PCO) and inositol. By taking not only did her insulin sensitivity improve, the researchers also noticed improved fertility. (R)
Inositol substitution can also be beneficial for other diseases, such as non-alcoholic fatty liver disease (NAFLD). (R) In patients with an underactive thyroid, a combined intake of selenium and inositol was able to lower the hormone TSH and reduce antibodies against the thyroid gland. This alleviated the symptoms of hypothyroidism. (R)
With this wide range of uses and the many clinical research studies, inositol is a promising molecule for the future.
Inositol plays a role here: Immune system, sugar and fat metabolism and hormone balance
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Altered intercellular communication
- Mitochondrial dysfunction
- Loss of proteostasis
Creatine monohydrate
Creatine is an essential. With the help of this molecule the muscle's own ATP reserves can be increased, which is noticeable as increased strength. As we age, our body's own creatine production decreases, which is why it makes sense for non-athletes to take creatine. (R) From the 50th As you age, muscle mass decreases by 1-2% per year, and muscle strength even decreases by 1-5%. (R,R,R) We can compensate for this for a long time, but at some point the muscles are so weak that even previously simple things, like climbing stairs, become more difficult become. For this reason, Strength training in combination with creatine is an effective approach to maintaining muscle strength in old age.
Creatine study situation:
In addition to its strength-enhancing effect creatine dampens inflammatory processes in the body and thus supports your immune system. (R) In addition, creatine leads to improved cognitive performance and in animal studies offered protection against neurodegenerative diseases by eliminating lipofuscin in the brain, too known as “aging pigment”. (R)
Creatine also seems to have a positive effect on depression. In a randomized, double-blind study (conforming to the highest standard of science), creatine supported the absorption and effects of SSRIs, a group of antidepressants. (R)
Creatine plays a role here: Immune system, muscle and bone metabolism, cognitive performance
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Altered intercellular communication
- Mitochondrial dysfunction
- Loss of proteostasis
Magnesium taurate
Magnesium is the eighth most common element in the earth's crust and comes in various, chemically bound forms before. In our body magnesium is involved as a co-factor in more than 300 enzymes, which have a wide variety of functions in the body. From protein biosynthesis, through muscle and nerve signals to the regulation of blood sugar and blood pressure. (R) According to the National Consumption Study II of the Federal Ministry of Food, Agriculture and Consumer Protection the majority of people consume too little magnesium. (R)
Magnesium study situation:
A Magnesium deficiency is associated with some important “age-related diseases”, such as arteriosclerosis, elevated blood lipid levels, Alzheimer’s disease and type 2 diabetes mellitus. (R) The functions of magnesium in the body are diverse, as shown by the number of enzymes in which magnesium is involved. It also helps stabilize the genome and thereby reduces DNA damage. (R,R)
The organic compound of the amino acid taurine with magnesium also ensures improved bioavailability and in addition, Taurine also acts as a mediator for healthy mitochondria. (R,R) Magnesium reduces tiredness and exhaustion, promotes your energy metabolism and calms the nerves.
Here Magnesium taurate plays a role: Immune system, muscle metabolism, cognitive performance, sleep, energy metabolism, cardiovascular health, insulin sensitivity
Hallmarks of Aging:
- Inflammaging – inflammatory aging
- Mitochondrial dysfunction
- Genomic instability
- Telemor Abrasion
- Deregulated nutrient measurement
Citrulline malate
The amino acid L citrulline occurs naturally in watermelon and is involved, for example, in the urea cycle in the liver and kidneys. L-citrulline leads to improved nitric oxide (NO) production in the body. To achieve this effect, however, you would have to consume at least 1-1.5kg of watermelon - per day! (R)
Malate is the salt of malic acid and occurs in the body, among other things, in the citrate cycle. Just like alpha ketoglutarate.
Citrulline studies:
Nitrogen monoxide (NO) is needed by our vessels so that they dilate (vasodilation). As we age, our cardiovascular health tends to worsen, NO levels fall and blood pressure rises. (R) For this reason, it can be advantageous if the body's own NO production is increased again. In principle, L-arginine and L-citrulline are suitable for this, as both are involved in nitrogen metabolism. Although L-arginine is the direct precursor of NO, L-arginine supplementation is not effective and leads to more side effects. L-citrulline in combination with malate is better absorbed and is more effective in increasing NO synthesis. (R,R)
The increased NO production also benefits your muscles. You can generate more power through the increased blood flow. (R)
Malate has been shown to improve lifespan and mitochondrial function in animal studies. (R,R). As part of the citrate cycle, malate is involved in the production of energy in the form of ATP. Supplementation in mice showed increased energy production. (R)
L-citrulline malate plays a role here: Energy metabolism, cardiovascular system
Hallmarks of Aging:
- Mitochondrial dysfunction
- Dysregulated nutrient measurement & fasting
Vitamin C (ascorbic acid)
Our body cannot produce Vitamin C itself, which is why we depend on our food. If we don't do this sufficiently, we can become seriously ill. In the past, sailors in particular often had a vitamin C deficiency due to a lack of fresh fruit, which manifested itself in the disease scurvy . (R,R)
Vitamin C has a variety of roles in the body. It contributes to normal immune function, supports energy balance, helps with muscle recovery, is involved in collagen formation for skin and bones and protects you from infections. (R,R,R)
Vitamin C study situation:
Vitamin C as a single molecule is not associated with greater longevity - at least there are no studies on it (yet). However, it does have some synergistic effects, especially with alphaketoglutarate. In addition, vitamin C is being researched as an additive in the treatment of cancer (R) and it helps shorten the duration of colds. (R)
Vitamin C plays a role here: Energy metabolism, immune system
Hallmarks of Aging:
- Genomic instability
- Telomere shortening
- Loss of protostasis
- Cellular senescence
- Mitochondrial dysfunction
- Epigenetic change
- altered intercellular communication
