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Magnesium citrate

Magnesium citrate

magnesium is an essential mineral for our body, involved in more than 300 biochemical reactions. It is crucial for energy metabolism, the function of heart and muscle cells, and for bone health. In nature, magnesium occurs almost exclusively in compounds with various other elements. The range of magnesium supplements is similarly broad. But what makes, for example, Magnesium bisglycinate compared to magnesium citrate special? And why do people prefer Magnesium oxide in the treatment of constipation, while Magnesium sulfate in the treatment of hypertension during pregnancy Application? In this series of articles, we will examine the different magnesium compounds and their specific benefits. Basic information about magnesium can be found in our introductory article "What is magnesium?“. In this article we focus on the properties and applications of Magnesium citrate.

What is magnesium citrate?

Magnesium citrate is the Magnesium salt of citric acid, a compound that is used both in medicine and as Dietary supplements It is often used for its laxative effect. Due to its good bioavailability, it is easily absorbed by the body and is available as a source of magnesium. There are also various spellings for the molecule. Both magnesium citrate and magnesium citrate can be found in the literature.

Natural occurrence of magnesium citrate

Magnesium citrate does not occur naturally in significant quantities. Instead, it is produced synthetically, e.g., through the chemical reaction of magnesium oxide, magnesium hydroxide, or magnesium carbonate with citric acid. This process binds the magnesium to the citric acid, producing water and/or carbon dioxide as a byproduct.

Absorption of magnesium citrate

The absorption of magnesium citrate in the human body is higher than that of other magnesium compounds such as magnesium oxide. Its improved solubility in water promotes the availability of magnesium for absorption in the digestive tract. This can achieve a bioavailability of up to 80%. By comparison, magnesium oxide has an availability of only about 4%.

Magnesium citrate as a dietary supplement

Magnesium citrate is valued as a dietary supplement because it is effective in preventing and Treatment of magnesium deficiency can be used. In our overview article on magnesium, we already discussed some of the areas in which magnesium plays a role in your body. Here we show you the specific uses of magnesium citrate.

Magnesium citrate for migraines

Magnesium citrate is increasingly recognized as an effective preventive treatment for migraine, based on the knowledge that magnesium deficiency is often observed in people with frequent migraine attacks.Magnesium plays an important role in numerous physiological processes associated with the pathophysiology of migraine, including neurotransmitter release, regulation of vascular constriction, and inflammatory responses. Magnesium citrate supplementation may help reduce the frequency, duration, and severity of migraine attacks by supporting cerebral neuronal function and improving vasomotor stability. Also in the Guideline Magnesium is mentioned as a therapeutic option for the treatment of migraine attacks and prophylaxisAlthough magnesium is less effective than other medications, it is significantly fewer side effects.

Also helpful for kidney stones:

Magnesium citrate has proven to be helpful in the treatment of kidney stones, especially in Prevention of calcium oxalate stones, the most common type of kidney stone. The mechanism by which magnesium citrate works is that Magnesium combines with oxalate in the intestine, which the Absorption of oxalate and thus reduces its availability in the urine. By reducing the amount of oxalate available to bind with calcium, the formation of calcium oxalate stones is inhibited. Furthermore, magnesium citrate increases the pH of the urine, which can further reduce the risk of stone formation, as more alkaline urine increases the solubility of calcium oxalate. For these reasons, magnesium citrate may be helpful for people prone to kidney stones. It reduces the likelihood of stone formation, as this Review represents.

Magnesium citrate against arteriosclerosis

One of the largest research areas for magnesium and the longevity is the so-called ROADMAP study. This is still ongoing as of 2024 and therefore the results have not yet been published. The idea behind it is that Magnesium, together with calcium and phosphate, plays an important role in the calcification of arteries. When this balance is disturbed, vascular calcification occurs more rapidly. The researchers now want to find out whether supplementing with magnesium citrate, with or without an additional phosphate binder, can reduce arterial stiffness and calcification. We explain why arteriosclerosis is such an important topic and how the process behind it works here:

What is arteriosclerosis?

The calcification of the arteries, also known as arteriosclerosis is a complex process that leads to Deposition of calcium phosphate crystals in the walls of the blood vessels. This can Reduce elasticity of the arteries and lead to a variety of cardiovascular diseases, including heart attack, stroke, and peripheral arterial disease.The process of calcification involves several key minerals, particularly magnesium, phosphate and calcium, which play a central role in the pathophysiology of this disease.

The process of arteriosclerosis

  • Initiation: Calcification often begins with Damage to the inner layer the artery wall, the endothelium. This damage can be caused by various factors, including high cholesterol, high blood pressure, smoking, and inflammation. Read more about this in our Blood lipid levels-Article.
  • Inflammatory reaction: The damage is followed by an inflammatory reaction in which cholesterol and other substances are deposited in the artery wall, forming plaque. Calcium and phosphate begin to accumulate in these plaques, leading to further hardening and thickening of the artery wall.
  • Progression: Over time, the plaque can grow and further restrict blood flow through the artery. Pieces of the plaque can break off and cause blood clots, which can block blood flow.

Role of magnesium, phosphate and calcium

  • Calcium: It's an essential component of bones and teeth, but also plays a key role in arterial calcification. Calcium ions accumulate in plaques, contributing to the hardening and thickening of arteries.
  • phosphatePhosphates, along with calcium, form the calcium phosphate crystals found in plaques. High phosphate levels in the blood can promote calcification by facilitating the formation of these crystals.
  • magnesium: Magnesium acts as natural calcium channel blocker and can Reduce calcium deposition in the artery wall. It also has anti-inflammatory properties and can contribute to the stabilization of plaques, thereby reducing the risk of rupture and subsequent vascular occlusion. Adequate magnesium levels can therefore have a protective effect against arterial calcification.

Did you know?

The Combination of vitamin D3 and vitamin K2 plays a crucial role in the prevention of arteriosclerosis, a key risk factor for cardiovascular disease. Vitamin D3 promotes the absorption of calcium from the intestines, while vitamin K2 helps to transport this calcium into the bones and teeth and keep it away from the artery walls. Vitamin K2 specifically activates the matrix Gla protein (MGP), one of the strongest inhibitors of arterial calcification. MGP prevents the deposition of calcium in the blood vessel walls. Without sufficient amounts of vitamin K2, vitamin D3 Increased calcium can be mistakenly deposited in the arteries, leading to calcification.Through their synergistic action, vitamins D3 and K2 ensure that calcium gets to where it is needed (into the bones) and prevent it from being deposited in the arteries, thus minimizing the risk of calcification and associated cardiovascular problems.

Preventive measures

Maintaining a healthy balance of calcium, phosphate, and magnesium is crucial to minimize the risk of arteriosclerosis. Dietary habits rich in magnesium-containing foods (such as green leafy vegetables, nuts and seeds), can help promote the balance of these minerals. In addition, measures to reduce the risk of endothelial damage, such as controlling blood pressure, lowering cholesterol levels, and quitting smoking, are crucial for preventing arteriosclerosis.

Arterial calcification is a multifactorial process in which magnesium may play a protective role by minimizing calcium deposition in the vessel walls and modulating the inflammatory response. A balanced diet and a healthy lifestyle are essential to reducing the risk of arteriosclerosis.

Forms of magnesium citrate

Now that we've looked at the uses of magnesium citrate, let's return to the actual molecule. Magnesium citrate is available in various forms, including capsules, tablets, and powder. The choice of form depends on personal preference, tolerance, and dosage requirements. Powder forms often offer more flexible dosage. In combination with other forms of magnesium, you'll also more commonly find magnesium citrate in magnesium complexes.

Magnesium Citrate vs. Magnesium Oxide

Magnesium citrate is compared to magnesium oxide because of its higher bioavailability and better absorption. However, magnesium oxide can be used as a more cost-effective alternative or when a stronger laxative effect is needed.

Differences between tri-magnesium dicitrate and magnesium citrate

  • Magnesium content: The main difference between tri-magnesium dicitrate and conventional magnesium citrate is the magnesium content. Tri-magnesium dicitrate contains more elemental magnesium, making it a more efficient source for those looking to increase their magnesium levels.
  • Bioavailability: Although both forms are known for their good bioavailability, the higher magnesium concentration in tri-magnesium dicitrate may lead to even more effective absorption, especially when a person needs to compensate for a significant magnesium deficiency.
  • Purpose and dosageNote: Due to the higher magnesium content in tri-magnesium dicitrate, a lower dosage may be required to achieve the same amount of elemental magnesium as with conventional magnesium citrate. This can be particularly useful when planning supplementation strategies.You can find Tri-Magnesium Dicitrate in our QNESIUM.

In the Everyday Essentials Bundle, you'll find three products for the most common deficiencies in humans. These include vitamin D, omega 3, and magnesium.

Side effects of magnesium citrate

Possible side effects of magnesium citrate include Gastrointestinal complaints, diarrhea and a laxative effect, especially at higher doses. Most side effects are mild and temporary.

Overdose of magnesium citrate

An overdose of magnesium (Hypermagnesemia) is rare and occurs most often in people with impaired kidney function. Symptoms may include:

  • Low blood pressure (hypotension)
  • Nausea and vomiting
  • Diarrhea
  • Lethargy or fatigue
  • Muscle weakness

Optimal use and dosage

The choice of magnesium citrate form (whether capsules, powder, or tablets) should be based on individual needs, preferences, and specific health goals. Ideally, you should take magnesium citrate with a meal to optimize absorption and minimize potential gastrointestinal upset. Dosage varies depending on age, gender, and health needs, but the general recommendations for daily magnesium intake are for adults between 310 and 420 mg.

Conclusion:

Magnesium citrate is an exciting member of the magnesium family. The molecule has already been investigated in several clinical studies and has proven effective in migraines and kidney stones. Research on magnesium and arteriosclerosis is exciting with regard to longevity. This would be a further step towards Healthspan to extend.

Literature

  • Silberstein, Stephen D. “Preventive Migraine Treatment.” Continuum (Minneapolis, Minn.) vol. 21.4 Headache (2015): 973-89. Link
  • “Magnesium Citrate.” Drugs and Lactation Database (LactMed®), National Institute of Child Health and Human Development, January 15, 2024. Link
  • Afitska, Kseniia et al. “Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial.” Magnesium research vol. 34,3 (2021): 130-139. Link
  • Vermeulen, Emma A et al. “Reversal Of Arterial Disease by modulating Magnesium and Phosphate (ROADMAP-study): rationale and design of a randomized controlled trial assessing the effects of magnesium citrate supplementation and phosphate-binding therapy on arterial stiffness in moderate chronic kidney disease.” Trials vol. 23,1 769. 12 Sep. 2022, Link
  • Barrett, Hilary et al. “Is Matrix Gla Protein Associated with Vascular Calcification? A Systematic Review.” Nutrients vol. 10,4 415. 27 Mar. 2018, Link

Table of contents

Tocotrienols (vitamin E)

tocotrienols are a special form of vitamin E, which are characterized by their unique chemical structure and potential health benefits. In contrast to tocopherols, the more common forms of vitamin E, tocotrienols have shorter saturated side chains, which allows them to penetrate cell membranes more efficiently and antioxidant effects These properties make them particularly effective in protecting cells from oxidative stress and free radical damage. Studies have shown that tocotrienols can provide anti-inflammatory, neuroprotective and cardiovascular benefits, making them an important part of a health-promoting diet. Their importance for human health extends to various areas, including the prevention of chronic diseases and the promotion of healthy ageing.

Tocotrienol Effect: How do tocotrienols work in the body?

Tocotrienols are known for their potent antioxidant properties that go far beyond those of tocopherols. They work in the body by penetrating cell membranes and incorporating themselves into the lipid bilayers of cell membranes. This property allows them to act effectively against oxidative damage caused by free radicals. Free radicals are unstable molecules that can damage cells and contribute to chronic diseases and aging processes.

The antioxidant abilities of tocotrienols play an essential role in neutralizing these harmful molecules. By reducing oxidative stress, tocotrienols can protect the integrity of cell membranes and DNA, which in turn helps prevent cancer, cardiovascular disease, and neurodegenerative diseases. In addition, studies have shown that tocotrienols have anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines. This may help reduce chronic inflammation associated with many age-related diseases.

In addition to their antioxidant and anti-inflammatory properties, tocotrienols also have a neuroprotective effectThey promote the survival of nerve cells and protect the brain from ischemic damage, which is particularly important in the prevention of strokes and other neurological diseases. In addition, tocotrienols support cardiovascular health by regulating cholesterol levels and preventing the formation of atherosclerotic plaques.

Tocotrienols vs. Tocopherols: The Difference Explained

While tocotrienols and tocopherols both belong to the vitamin E family, they differ significantly in their chemical structure and biological effects. Tocopherols have a saturated side chain, while tocotrienols have an unsaturated side chain. These structural differences give tocotrienols a greater ability to penetrate cell membranes and enter the lipid bilayer.

Another significant difference lies in their antioxidant capacities. Tocotrienols are up to 50 times more effective than tocopherols in combating lipid peroxidative damagecaused by free radicals. This makes them particularly effective in protecting cell membranes and lipoproteins from oxidative stress.

In addition, tocotrienols show a stronger effect on the Inhibition of cholesterol synthesis in the liver.This happens by suppressing the enzyme HMG-CoA reductase, which plays a key role in the cholesterol production This property makes tocotrienols a promising agent for lowering LDL cholesterol levels and promoting heart health.

In addition, tocotrienols have specific effects on cancer prevention that are not observed to the same extent with tocopherols. They can inhibit the growth of cancer cells, promote their apoptosis (programmed cell death) and suppress angiogenesis (formation of new blood vessels) in tumors.

Due to these unique mechanisms of action, tocotrienols deserve special attention in research and clinical application. Their ability to go beyond pure antioxidant effects and provide comprehensive health benefits sets them apart from tocopherols and makes them an important part of a health-promoting diet and supplementation.

Vitamin E Tocotrienols: Specific Benefits for Longevity

Tocotrienols, a lesser-known form of vitamin E, play a remarkable role in promoting health and longevity. Their unique chemical properties allow them to efficiently penetrate cell membranes and exert powerful antioxidant effects. These abilities are crucial for protecting cells from oxidative damage that can contribute to aging processes and chronic diseases. Studies have shown that tocotrienols not only reduce oxidative damage but also improve cell function and integrity, leading to a healthier and potentially longer life.

Cell Protection and Antioxidants: The Role of Tocotrienols

One of the outstanding properties of tocotrienols is their ability to act as powerful antioxidants. These substances neutralize free radicals, the unstable molecules that can damage cells and accelerate the aging process. Free radicals are created by normal metabolic processes as well as by external factors such as pollution and UV radiation. Tocotrienols protect cells by intercepting and neutralizing these harmful molecules before they can cause damage. This helps maintain cell health, reduce the risk of DNA damage and thus prevent the development of cancer and other degenerative diseasesTheir ability to penetrate the lipid bilayer of cell membranes makes tocotrienols particularly effective in protecting cell structure and function.

Anti-inflammatory properties of tocotrienols

In addition to their antioxidant abilities, tocotrienols also have powerful anti-inflammatory properties. Chronic inflammation is a known risk factor for many age-related diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders. Tocotrienols exert anti-inflammatory effects by inhibiting the activity of enzymes and molecules that promote inflammatory responses. For example, they block the production of pro-inflammatory cytokines and reduce the expression of enzymes such as cyclooxygenase-2 (COX-2), which are involved in inflammatory processes. By reducing these inflammatory markers, tocotrienols help reduce the risk of chronic inflammation and related diseases. Their anti-inflammatory effects therefore not only support general health but also promote a long and healthy life.

By combining their antioxidant and anti-inflammatory effects, tocotrienols offer comprehensive benefits for longevity and healthy aging. Their ability to prevent cellular damage and reduce inflammation makes them a valuable component of a health-promoting diet and potentially also an effective supplement to promote quality of life in old age.

Tocotrienols in food: Where can you find them?

Tocotrienols are found in various plant foods, which serve as excellent sources of this valuable form of vitamin E. These foods can be easily incorporated into your daily diet to reap the health benefits of tocotrienols.

palm oil

One of the richest natural sources of tocotrienols is palm oil, particularly red palm oil. It contains high concentrations of all four forms of tocotrienols (alpha, beta, gamma and delta tocotrienol). Palm oil can be used in cooking and adds a mild flavor to dishes while also having a high heat tolerance.

rice bran oil

Rice bran oil is another oil rich in tocotrienols. It is extracted from the tough outer shell of the rice grain and is widely used in many Asian cuisines. Rice bran oil can be used for frying, baking or as an ingredient in salad dressings.

barley

Barley, a grain grown in many parts of the world, also contains tocotrienols. Barley can be prepared in soups, stews, or as a side dish. It not only provides tocotrienols, but also fiber and other important nutrients.

Oats

Similar to barley, oats also contain tocotrienols. Oatmeal for breakfast or oatmeal cookies are easy ways to incorporate oats into your diet while benefiting from their vitamin E content.

wheat germ oil

Wheat germ oil, which is extracted from the germ of the wheat grain, is another good source of tocotrienols. It can be used as a cooking oil or mixed into smoothies and dressings. Wheat germ oil is sensitive to high temperatures, so it is preferably used raw or at low temperatures.

annatto oil

Annatto oil, which is extracted from the seeds of the annatto shrub, is particularly rich in delta and gamma tocotrienols. It is often used as a natural coloring and flavoring in foods and can also be used as a cooking oil.

nuts and seeds

Some nuts and seeds, such as almonds, hazelnuts and sesame seeds, also contain smaller amounts of tocotrienols along with other forms of vitamin E. They can be eaten as a snack or used in various dishes.

Green leafy vegetables

Certain green leafy vegetables, such as spinach and kale, also contain tocotrienols. These vegetables can be prepared in salads, smoothies, or as a side dish to add extra vitamin E content to the diet.

whole grain products

Whole grains such as whole wheat bread, whole wheat pasta and brown rice also contain tocotrienols. Eating whole grains instead of refined grain products not only improves the absorption of tocotrienols but also provides additional fiber and nutrients.

What is Vitamin E for? General Health Benefits

Vitamin E is an essential fat-soluble antioxidant that offers a variety of health benefits.It plays a central role in various biological processes and contributes significantly to maintaining health.

skin health

Vitamin E is widely known for its beneficial effects on the skin. As a powerful antioxidant, it protects skin cells from oxidative stress and free radical damage caused by UV radiation and pollution. It can help slow skin aging, reduce wrinkles, and improve skin elasticity. Vitamin E is often used in skin care products to moisturize and promote the healing of scars and wounds.

immune function

Another significant benefit of vitamin E is its role in supporting the immune system. It strengthens the immune response by improving the function of immune cells. Studies have shown that adequate vitamin E can reduce the risk of infections, especially in older adults. It supports the formation of T lymphocytes and the production of antibodies, which are important for fighting off pathogens.

cardiovascular health

Vitamin E plays an important role in maintaining cardiovascular health. It helps prevent the oxidation of LDL cholesterol (the "bad" cholesterol), which in turn reduces the formation of plaque in the arteries and lowers the risk of atherosclerosis and heart disease. In addition, vitamin E can improve blood vessel function and reduce platelet aggregation, thus minimizing the risk of blood clots.

eye health

Vitamin E also has beneficial effects on eye health. It can reduce the risk of age-related macular degeneration (AMD) and cataracts, which can lead to visual impairment and blindness. As an antioxidant, it protects the cells of the lens and retina from oxidative stress and helps maintain good vision.

brain health

The neuroprotective properties of vitamin E may help protect against neurodegenerative diseases such as Alzheimer's and Parkinson's. Vitamin E protects nerve cells from oxidative damage and inflammation, which can lead to degeneration of the nervous system. Studies have shown that adequate vitamin E intake can improve cognitive function and memory in older people.

Hormonal Balance

Vitamin E has a positive effect on hormonal balance, especially in women. It can relieve symptoms of premenstrual syndrome (PMS) by reducing the pain and discomfort during the menstrual cycle. Vitamin E can also help women going through menopause to reduce hot flashes and other symptoms.

cell protection and DNA repair

As an antioxidant, vitamin E plays an essential role in protecting cell membranes and DNA from oxidative damage. It helps maintain the integrity of cell structures and contributes to the repair of damaged DNA. This supports overall cellular health and may reduce the risk of cancer and other degenerative diseases.

muscle regeneration and athlete health

For athletes and physically active people, vitamin E may also be beneficial. It supports muscle recovery after intense exercise by reducing muscle inflammation and damage. Vitamin E may improve endurance and performance by optimizing oxygen supply to muscles and reducing the formation of lactic acid.

wound healing

Vitamin E promotes the healing of wounds and scars by accelerating the regeneration of skin cells and reducing inflammation. It can be used both internally through supplements and externally through creams and oils to support the healing process.

Side Effects of Vitamin E: What You Should Know

Vitamin E is generally considered safe and healthy known, however, side effects can occur both naturally and when taken as a supplement. These can vary depending on the dosage and individual sensitivity. Here are some of the most important points to consider:

Possible side effects at high doses

At very high doses, vitamin E can be toxic. An overdose, especially from dietary supplements, can lead to various health problems. The most common side effects include:

  • gastrointestinal problems: High doses of vitamin E can cause nausea, diarrhea, abdominal cramps and general gastrointestinal discomfort.
  • bleeding tendency: Vitamin E has blood-thinning properties, so an overdose may increase the risk of bleeding. This is especially important for people taking blood thinners or suffering from bleeding disorders.
  • headaches and dizziness: Some people report headaches and dizziness when taking high doses of vitamin E.
  • muscle weakness and fatigue: In rare cases, an overdose may cause muscle weakness and general tiredness.

interactions with medications

Vitamin E may interact with certain medications, especially blood thinners such as warfarin and aspirin. These interactions can further increase the risk of bleeding. Also, when taking chemotherapy drugs, vitamin E can interfere with the effectiveness of the treatment. It is therefore important to consult a doctor before taking vitamin E supplements if you are taking regular medications.

Safety in natural intake

The recording of Vitamin E through diet is considered safe and is associated with a lower risk of side effects. Foods such as nuts, seeds, vegetable oils, and green leafy vegetables provide vitamin E in amounts that do not normally cause adverse effects.

Tocotrienol side effects: Are there any risks?

Tocotrienols, a special form of vitamin E, also have numerous health benefits but can have side effects if used improperly.

Possible side effects of tocotrienols

Although tocotrienols are generally well tolerated, they can cause side effects in high doses or in sensitive individuals. Possible side effects include:

  • Gastrointestinal complaints: Similar to general vitamin E, high doses of tocotrienols can cause gastrointestinal problems such as nausea, diarrhea, and abdominal pain.
  • headaches and dizziness: Headaches and dizziness can also occur as side effects, especially at higher doses.
  • risk of bleeding: Due to their blood-thinning properties, tocotrienols may increase the risk of bleeding, especially when taken at the same time as anticoagulants or in people with bleeding disorders.

Vitamin E Weight Gain: Truth or Myth?

Vitamin E is known for its antioxidant properties and numerous health benefits, but there is some misconception about whether it can contribute to weight gain.

Scientific findings

There is no conclusive scientific evidence that vitamin E directly contributes to weight gain. Vitamin E is a fat-soluble vitamin found primarily in vegetable oils, nuts, and seeds. These foods are high in calories, which may have led to confusion.

  • Calorie content of vitamin E-rich foods: Many foods rich in vitamin E also contain high amounts of fat, such as nuts and vegetable oils. Eating large amounts of these foods can lead to increased calorie intake, which could theoretically contribute to weight gain. In this case, however, it is not the vitamin E itself but the increased calorie consumption that affects weight.
  • Functions of Vitamin E in the Body: Vitamin E plays an important role as an antioxidant and supports several functions in the body, including cellular health and the immune system. However, there is no evidence that vitamin E affects metabolism in a way that directly leads to weight gain.

studies and research results

Several studies have attempted to examine the relationship between vitamin E and weight gain, but without clear evidence of a direct link:

  • Weight Control and Antioxidants: Some studies have shown that antioxidants, including vitamin E, may play a role in regulating metabolism and reducing inflammation. This could theoretically contribute to better weight control, especially by improving overall health and well-being.
  • nutritional studies: Dietary studies examining the consumption of vitamin E-rich foods have found no significant association between vitamin E and weight gain. Rather, a balanced diet rich in nutrients and low in processed foods appears to regulate body weight naturally.

The idea that vitamin E causes weight gain is largely a myth. There is no scientific evidence that vitamin E directly increases body weight. Instead, the misconception may be due to the high calorie content of vitamin E-rich foods. A balanced diet and calorie-conscious use are crucial for weight management. Vitamin E plays an important role in overall health, but it should be consumed as part of a balanced and nutrient-rich diet.

How much vitamin E per day? Recommendations for the daily dose

Vitamin E is an essential fat-soluble antioxidant necessary for maintaining good health. Daily intake of vitamin E varies depending on age group, gender and specific health conditions.Here are the general recommendations for daily vitamin E intake, based on scientific guidelines and current research.

Recommended daily dose

The recommended daily allowance (RDA) of vitamin E is measured in milligrams (mg) of alpha-tocopherol, the most abundant form of vitamin E in the body. The RDA was established by the US National Institutes of Health (NIH).

  • infants
  • 0-6 months: 4 mg per day
  • 7-12 months: 5 mg per day
  • Children
  • 1-3 years: 6 mg per day
  • 4-8 years: 7 mg per day
  • 9-13 years: 11 mg per day
  • adolescents and adults
  • Men aged 14 and over: 15 mg per day
  • Women over 14 years: 15 mg per day

upper limit of safe intake

The tolerable upper intake level (UL) defines the highest amount of vitamin E that is unlikely to have adverse health effects when taken long-term. These values ​​were also established by the NIH:

  • Children
  • 1-3 years: 200 mg per day
  • 4-8 years: 300 mg per day
  • 9-13 years: 600 mg per day
  • adolescents and adults
  • From 14 years: 1000 mg per day

These upper limits apply mainly to vitamin E from dietary supplements and fortified foods, since high doses from natural foods are rarely achieved.

Sources of Vitamin E

Vitamin E is found in a variety of foods and can be easily obtained through the daily diet.

  • nuts and seeds: almonds, sunflower seeds, hazelnuts
  • Vegetable oils: wheat germ oil, sunflower oil, safflower oil, olive oil
  • Green leafy vegetables: spinach, kale
  • whole grain products: whole grain bread, brown rice
  • fruit and vegetables: Avocados, tomatoes, sweet potatoes

Daily intake of vitamin E is crucial for maintaining good health and can be easily achieved through a balanced diet. Recommended daily doses vary according to age group and specific conditions. Be sure to meet your vitamin E intake both from natural foods and, if necessary, from supplements, and avoid overdoses by respecting the established upper limits.

Conclusion on Tocotrienols & Vitamin E

Tocotrienols, a special form of vitamin E, have gained increasing attention in recent years due to their unique health benefits. They are structurally and functionally distinct from the more well-known tocopherols and offer a wide range of potential health benefits.

Tocotrienols are a valuable component of vitamin E with a variety of health benefits. Their powerful antioxidant and anti-inflammatory properties make them an important nutrient for supporting cardiovascular health, neurological function, skin health, and possibly even cancer prevention.By following safe intake guidelines and favoring natural sources, tocotrienols can be effectively integrated into a healthy diet to fully exploit their beneficial effects.

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Folic acid (vitamin B9)

What is folic acid?

folic acid, also known as vitamin B9, is a water-soluble vitamin that belongs to the B vitamins. Chemically, folic acid consists of a pteridine ring, a para-aminobenzoic acid (PABA) and a glutamic acid. This structure allows the vitamin to play an essential role in various biochemical reactions in the body.

Folic acid is essential for numerous vital processes in the human body. It is involved in DNA synthesis and repair, thereby supporting cell division and growth. It also plays an important role in the formation of red blood cells, which is crucial for oxygen transport in the blood. Adequate folic acid levels are therefore particularly important for pregnant women to prevent malformations in the fetus, as well as for all people to maintain good health and longevity.

Why is folic acid important?

Folic acid, an essential B vitamin (vitamin B9), is of great importance for the human body and fulfills several basic functions:

DNA synthesis and cell division

Folic acid plays a central role in DNA synthesis and repair. It is involved in the formation of nucleotides, the building blocks of DNA. This is especially important during periods of rapid growth such as pregnancy, childhood and puberty, as these are times when there is increased cell division and proliferation.

blood formation

Another important aspect of folic acid is its involvement in blood formation. It promotes the production and maturation of red blood cells in the bone marrow. A deficiency in folic acid can lead to a form of anemia known as megaloblastic anemia. This condition is characterized by large, immature red blood cells that cannot carry oxygen effectively.

amino acid metabolism

Folic acid is also involved in amino acid metabolism, especially in Conversion of homocysteine ​​to methionine. Increased homocysteine ​​levels in the blood are associated with a higher risk of cardiovascular disease. By supporting the homocysteine ​​degradation Folic acid contributes to heart health.

nervous system

Folic acid plays a supportive role in the nervous system by promoting the synthesis of neurotransmitters, which are necessary for signal transmission between nerve cells. Adequate levels of folic acid can therefore help maintain good cognitive function and mental health.

Folic Acid Deficiency: Causes and Effects

Insufficient dietary intake

One of the most common causes of folic acid deficiency is inadequate intake through food. People who do not eat a balanced diet or who eat little fruit, vegetables and whole grain products are particularly at risk.

Increased demand

Certain phases of life and conditions such as Pregnancy, breastfeeding, puberty and illnesses can increase the need for folic acid. For example, pregnant women need a higher amount of folic acid to support the growth of the fetus.

diseases of the digestive tract

Diseases that affect the absorption of nutrients in the intestine, such as celiac disease, Crohn's disease or inflammatory bowel disease, can lead to a folic acid deficiency. Surgical interventions on the digestive tract can also negatively affect the absorption of folic acid.

alcohol abuse

Excessive alcohol consumption can significantly impair the absorption and metabolism of folic acid. Alcohol interferes with the conversion of folic acid into its active form and increases its excretion via the kidneys.

Drug influences

Certain medications such as anticonvulsants (used to treat epilepsy), methotrexate (a cancer drug), and some antibiotics can interfere with how the body absorbs or uses folic acid.

Effects of a folic acid deficiency

Megaloblastic anemia

Megaloblastic anemia is a common consequence of folic acid deficiency. This type of anemia is characterized by the production of abnormally large and immature red blood cells that cannot perform their function properly. Symptoms include fatigue, weakness, shortness of breath, and pale skin.

Cognitive impairments

Low folic acid levels are associated with cognitive impairment and an increased risk of dementia. A deficiency can negatively affect mental performance and memory, particularly in older people.

cardiovascular diseases

Elevated levels of homocysteine ​​in the blood, caused by a folic acid deficiency, are a risk factor for cardiovascular disease. Homocysteine ​​can damage the artery walls and contribute to the formation of blood clots.

depression and mood swings

There is evidence that folic acid deficiency may also be linked to mental health problems such as depression and mood swings. Folic acid plays a role in the synthesis of neurotransmitters that regulate mood.

Folic Acid and Longevity

The importance of folic acid for longevity is increasingly supported by scientific studies. Folic acid is an essential B vitamin, which plays a central role in numerous biological processes that are crucial for health and longevity.

One of the most important functions of folic acid is its involvement in DNA synthesis and repair. Studies show that adequate levels of folic acid help minimize genetic damage and maintain cell integrity. This is especially important because DNA damage and malfunctions in cell division are associated with the aging process and the development of diseases such as cancer.

Folic acid also helps break down homocysteine, an amino acid that can be harmful to blood vessels in high concentrations. Elevated homocysteine ​​levels are associated with a higher risk of cardiovascular disease. Studies suggest that folic acid supplementation may reduce the risk of such diseases by lowering homocysteine ​​levels and thus promoting heart health.

Low folate levels have also been linked to cognitive impairment and an increased risk of neurodegenerative diseases such as Alzheimer's. Research has shown that adequate folate intake can improve cognitive performance and protect the brain as we age.

In addition, folic acid potentially anti-inflammatory properties, which can contribute to overall health and longevity. Chronic inflammation is a known risk factor for many age-related diseases. By reducing inflammatory markers, folic acid can help reduce the risk of such diseases and improve the quality of life in old age.

Folic Acid and Weight Loss

The role of folic acid in weight loss is a topic that is attracting increasing interest in the scientific community and among health-conscious individuals. While folic acid is primarily known for its importance in DNA synthesis, cell division and blood formation, there is some evidence that it may also have an indirect effect on body weight.

Folic acid plays a central role in metabolism, particularly in amino acid and nucleotide metabolism. A well-functioning metabolism is crucial for efficient energy production and use in the body. Some studies suggest that optimal folic acid levels can support metabolism, which in turn could lead to better energy utilization and possibly also facilitate weight control.

Another aspect being investigated is the Relationship between folic acid and homocysteine ​​levels. High homocysteine ​​levels are associated with an increased risk of cardiovascular disease. Since folic acid helps lower homocysteine ​​levels, it may indirectly contribute to heart health. A healthy cardiovascular system is important for physical activity and endurance, which in turn can be helpful in weight loss.

There is also evidence that folic acid insulin sensitivity Improved insulin sensitivity means the body can more efficiently transport glucose from the bloodstream into cells, where it is used as energy or stored. This could help prevent blood sugar spikes and reduce the risk of type 2 diabetes, which may also have a positive effect on weight control. Read more about this in our article on insulin resistance.

An often overlooked factor in weight loss is mental health. Folic acid is involved in the synthesis of neurotransmitters such as serotonin, which regulate mood. A stable mood and low tendency toward depression can reduce emotional eating and thus support weight loss.

How much folic acid per day?

The recommended daily intake of folic acid varies depending on age, gender and life situation. To optimize health and avoid deficiencies, health authorities have established specific recommendations for daily folic acid intake.

The recommended daily dose of folic acid for adults is 400 micrograms (µg). This amount is sufficient to meet the needs of most people and ensure the normal functioning of the body. However, pregnant women have an increased need for folic acidto support the growth and development of the fetus and reduce the risk of neural tube defects. Therefore, they are recommended to receive a daily intake of 600 µg is recommended. Breastfeeding women should take about 500 µg per day to meet both their own needs and those of their child.

Children need different amounts of folic acid depending on their age. For infants up to six months, the recommended amount is 65 µg per day. For infants between seven and twelve months, the dose increases to 80 µg daily. Children aged one to three years should receive 150 µg per day, while four to eight-year-olds need 200 µg. Older children and adolescents need higher levels: nine to 13-year-olds should consume 300 µg per day, while adolescents aged 14 and over need the same dose as adults, namely 400 µg.

Too Much Folic Acid: Risks and Side Effects

While folic acid is an essential vitamin for numerous bodily functions, excessive intake can also pose health risks and side effects. It is important to keep a balance and not exceed the recommended daily intake unless specifically prescribed by a doctor.

masking a vitamin B12 deficiency

One of the most well-known disadvantages of excessive folic acid intake is the possibility to mask a vitamin B12 deficiency. Folic acid may mask the symptoms of megaloblastic anemia caused by B12 deficiency. This causes the B12 deficiency to go undetected and the underlying neurological damage to progress. This damage can have irreversible consequences, such as nerve damage and cognitive impairment.

impairment of the immune system

Excessive folic acid intake could impair the immune system. Some research has shown that too much folic acid can reduce the activity of natural killer cells, which play a key role in the immune system by attacking virus-infected cells and tumor cells.

Gastrointestinal complaints

High doses of folic acid can cause gastrointestinal problems such as nausea, bloating and abdominal pain. Although these side effects are usually mild, they can be unpleasant and affect the quality of life in sensitive people.

sleep disorders and behavioral problems

There is some evidence that an overdose of folic acid can cause sleep disturbances and behavioral problems such as irritability and hyperactivity in some people. This is particularly important in children, who may be more sensitive to high doses of folic acid.

Foods with folic acid

Folic acid, also known as vitamin B9, is an essential vitamin found in many foods. Here is a detailed list of foods that are particularly rich in folic acid, as well as tips for incorporating these foods into your daily diet.

green leafy vegetables

  • spinach: One of the best natural sources of folic acid. One cup of cooked spinach contains about 263 mcg of folic acid.
  • kale: Contains about 85 µg of folic acid per cup.
  • romaine lettuce: One cup contains about 64 µg of folic acid.

legumes

  • lenses: Half a cup of cooked lentils contains about 179 µg of folate.
  • chickpeas: Contains about 141 µg of folic acid per half cup.
  • black beans: Half a cup provides about 128 µg of folic acid.

whole grain products

  • Fortified bread and cereals: Many breads and breakfast cereals are fortified with folic acid and can contain up to 400 µg of folic acid per serving.
  • quinoa: One cup of cooked quinoa contains about 78 µg of folate.

fruit

  • oranges: A medium-sized orange contains about 40 µg of folic acid.
  • papaya: One cup of diced papaya provides about 53 µg of folate.
  • bananas: A medium-sized banana contains about 24 µg of folic acid.

nuts and seeds

  • sunflower seeds: A quarter cup contains about 82 µg of folic acid.
  • linseed: Two tablespoons provide about 54 µg of folic acid.

Additional sources

  • eggs: One large egg contains about 22 µg of folic acid.
  • liver: Chicken or beef liver are extremely rich in folate; 100 grams of beef liver contains about 212 µg of folic acid.
  • avocado: Half an avocado provides about 59 µg of folic acid.

When should you take folic acid?

The optimal time to take folic acid may vary depending on individual needs and health goals, but there are some general recommendations that can help maximize the effectiveness of folic acid intake.

In the morning with breakfast

A common recommendation is to take folic acid in the morning with breakfast. This has several advantages:

  • Better absorption: Taking folic acid with a meal containing other vitamins and minerals may improve absorption. Folic acid is best absorbed in a slightly acidic environment, which can be aided by foods such as fruit and whole grains.
  • regularity: Breakfast is a meal that many people eat regularly. Taking supplements at the same time each day helps establish a routine and ensure consistency.

Spread throughout the day

For individuals who require higher doses of folic acid, such as pregnant women or people with certain health conditions, it may be beneficial to spread the dose throughout the day. This can help keep blood folate levels stable and maximize bioavailability.

  • Multiple daily intake: Divide the daily dose into two or three smaller doses taken with main meals. This can be especially useful if you are using supplements with high dosages.

Before going to bed

Some people prefer to take folic acid before bed, especially if they take other supplements or medications that must be taken in the morning.

  • avoiding interactions: Taking folic acid in the evening may help avoid possible interactions with other supplements or medications taken in the morning.

Important instructions

  • Water: Always take folic acid with a glass of water to aid absorption and make it easier to take.
  • dietary supplements and medications: If you are taking other supplements or medications, talk to your doctor or pharmacist about the best time to take folic acid to avoid interactions.
  • consistency: Regardless of the time chosen, it is important to take folic acid at the same time every day to ensure a consistent supply.

Conclusion

Regular intake of adequate amounts of folic acid is crucial for maintaining good health and can make a significant contribution to a long and healthy life. Folic acid supports essential body functions, promotes cardiovascular health, supports mental performance and contributes to skin and hair health. A conscious diet, complemented by necessary supplements, ensures that the body is optimally supplied with this important vitamin. By ensuring that we have sufficient folic acid intake, we can improve our overall health and lay the foundation for a longer, healthier life.

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