More than 30 doctors, scientists, physiotherapists and nutritionists are at his side every day to optimize every little adjustment of his body. We are talking about the American entrepreneur Bryan Johnson, which with its rejuvenation program “Blueprint“ dedicated to eternal life.
He wakes up at 5:00 a.m. every morning, works out up to three times a day, eats a strict vegan diet that contains about 76% of his daily calories, and takes over 100 supplements a day to slow his aging.
At Bryan Johnson Blueprint, everything is questioned and testedBe it nutrition, sleep, blood values or fitness, everything is measured and compared with the latest research. Based on the vast amounts of data, the researchers create a detailed plan - initially "only" aimed at Bryan Johnson. He is therefore the guinea pig in his own project. He describes himself as "Professional Rejuvenation Athlete“ (Professional Rejuvenation Athlete) and as “the best-studied people in the world".
The remarkable thing about all his work is his openness. He shares all his routines, his fitness exercises and his supplement protocols for everyone to access on his website.
Attention: risk of confusion! Brian Johnson (with an i instead of a y) may sound very similar, but two people could hardly be more different. Brian (with an i), known on the internet as the "Liver King", eats raw organ meat and injects himself with steroids, while Bryan (with a y) follows a vegan diet.
October 2021 – the start of a new way of thinking
However, Bryan Johnson was not always as health conscious as he is now. As an initially unlucky entrepreneur, he made his breakthrough with companies like Braintree and VenmoThe sale of the two companies to eBay and Paypal catapulted the tech CEO into the circle of the richest people in the world. In 2023, his fortune is estimated at around 400 million US dollars.
However, entrepreneurial success came at a price. Due to the enormous stress levels, Johnson slipped into depression, neglected his own body and became increasingly overweight.
The Beginning of Bryan Johnson Blueprint
All that changed radically on October 13, 2021, when he announced his project Blueprint. The goal: to achieve maximum rejuvenation based on the latest scientific findings. In this project, opinions do not count, only facts. Today, Johnson employs a total of about 30 people and the project is costing him a lot. According to his own statements, the 45-year-old spends over two million dollars annually on the Longevity Project.
Bryan Johnson Blueprint – evidence-based, rigorous, transparent
In order to increase his credibility, Bryan Johnson publishes all of his test and laboratory results without exception. This not only increases transparency, but also makes it possible to verify the results of his methods more precisely. This practically makes Bryan Johnson a "transparent person".
Weight, body fat, muscle mass, oxygen saturation, sleep, temperature, blood sugar and air quality are measured regularly.But that is not all. While some people do not like visiting the doctor at all, Bryan Johnson almost weekly whole-body ultrasounds and MRIsin order to immediately detect structural changes (e.g. cancer) in the body.
Bryan Johnson is known for his iron discipline in various areas. He has improved his sleep with several tricks. In his bedroom no natural light comes in and he always tries to go to bed at the same time. In addition, there is No screen time 2 hours before bedtime and he wears special glasses that blue light block.
Sleep is actually a underestimated means of health and longevity to promote. During sleep, numerous regeneration processes are stimulated. Depending on the sleep phase, different parts of the body are regenerated.
A look into the supplement jungle
A central part of his eternity efforts are nutritional supplements and selected medications. According to his own statements, he takes the incredible amount of 111 supplements daily The number varies slightly because everything is always optimized according to needs.
All of these nutritional supplements have one purpose: to help Bryan Johnson reduce his biological age. Bryan Johnson started in 2021 with one goal in mind. He wanted to break the world record in “biological rejuvenation.” And he says he has impressively succeeded. He has heart of a 37-year-old, the skin of a 28-year-old and one Lung capacity that is otherwise only found in 18-year-olds can be found.
Together with a special, spermidine-rich greens drink, he swallows the 54 capsules and pills that are on the breakfast menu. The spectrum ranges from of plant extracts (ginger, turmeric, garlic), over well-known longevity supplements (calcium alpha-ketoglutarate, glucosamine, vitamin D3/K2, Omega-3 fatty acidn), up to medications (lithium, metformin).
Lunch is then scheduled daily at 11:00 a.m. The menu includes, for example, “Super Veggie“ – a creation made from black lentils and various vegetables and spices. Alternatively, Johnson also mentions “Nutty Pudding"As the name suggests, it is a kind of nut pudding with a variation of berries. Of course, the main meal, like breakfast, is accompanied by a lot of supplements.The tech entrepreneur takes the second dose of some molecules at lunchtime – new additions include hyaluronic acid.
Bryan Johnson Blueprint Diet – every single calorie is counted!
In addition to the supplements, which are all tailored to his personal needs, Bryan eats a very specific diet in which every single ingredient serves a "biochemical" purpose. In Super Veggie and Nutty Pudding, for example, the nutrient composition is not left to chance - quite the opposite.
The basic principles that Johnson follows in his diet are called caloric restriction and intermittent fasting. He only eats about 76% of the calories, measured by his daily basal metabolic rate, to slow down his aging. This value corresponds exactly to 1977 caloriesHe eats these calories in a window of 6-8 hours. Consequently, he fasts for 16-18 hours every day.
The number of calories is determined by the green breakfast drink, Super Veggie, Nutty Pudding and a third meal a day, which is comparatively variable – depending on which nutrients it needs at the time.
In the Japanese region of Okinawa (one of the five Blue Zones) people practice a similar diet and live significantly longer on average. Researchers have now been able to understand some of the aspects behind the Fast and why it can be beneficial for your health. The American Valter Longo has invented his own pseudo-fasting diet and the British singer Adele has Sirtfood diet can lose weight.
Fasting and diet, for example, affect the Hallmarks of Aging The Hallmarks of Aging are 12 different "markers" for health in old age. To do this, scientists Carlos López-Otin and Guido Kroemer evaluated more than 200 different studies. If you want to know more about this, you can read the detailed reports on the 12 different "markers" in our magazine.
Back to Bryan. In addition to the caloric restriction, the recipes are about Bryan’s body to provide enough proteinTo achieve this, he eats a large amount of lentils and pea protein every day. It is also important that his blood sugar does not fluctuate too much. To do this, Bryan tracks his blood sugar with a continuous glucose sensor. The aim is to prevent diabetes mellitus type 2 and its precursor, the insulin resistancez.
gadgets
To complement his diet and measurement routine, Johnson undergoes a whole host of rejuvenation treatments. Daily he "bathes" in red lightto activate its mitochondria and promote recovery after intense training sessions.One laser cap, which looks like a helmet, is intended to work in conjunction with a specially formulated tincture stimulate hair growth and restore color to individual gray hairs.
Bryan Johnson’s team also pays a lot of attention to his skin. A specially tailored Phototherapy, microbotox, microneedling and much more are designed to make the skin youthful again. You sleep on a special mattress that regulates the temperature and prevents nighttime stress caused by temperature fluctuations.
Bryan Johnson's community “Don't die”
Bryan Johnson is now a well-known personality not only in the longevity scene. His radical lifestyle and provocative videos/posts on social media have made the American an internet phenomenon.
He has long been selling his own olive oil or his famous “Nutty Pudding” at high prices. On Instagram, he can be seen with some world-famous stars, such as DJ Steve Aoiki, Andrew Huberman or the KardashiansHe invited the latter to his “Don’t die” dinner.
He unites a community of like-minded people under this slogan (in German: "Don't die"). On his website he describes the beliefs of this community. It almost seems like a religion with Bryan Johnson as the savior at the center.
Did you know?
Bryan Jonson comes from a Mormon community in Utah. After graduating from school, he spent two years as a Mormon missionary in Ecuador. He was a member of the church, which calls itself the "Church of Jesus Christ of Latter-day Saints," until he was 34. At the same time as leaving the church, he divorced his then wife and sold his company for $800 million.
Cerebrolysin – better than coffee?
On Bryan Johnson’s Instagram, you can find a video of the tech millionaire sticking a more than 3-centimeter-long syringe up his butt and injecting himself with a cloudy liquid. The molecule in this syringe is CerebrolysinIn that very video, the American enthuses that this molecule is better than Coffee and he feels clearer than ever.
Cerebrolysin is a neuroprotective drug made from hydrolyzed pig brain proteins. It contains a mixture of peptides and amino acids that have potential neurotrophic and neuroprotective effects. The drug has been studied for the treatment of neurological diseases such as stroke, Alzheimer's disease and traumatic brain injury. Researchers suspect several ways in which Cerebrolysin may work, including protection against apoptosis, an improved metabolism in the brain and also increased neurotransmission, i.e. improved communication between nerve cells.
What is behind the claim?
Should we all now give ourselves a shot of Cerebrolysin instead of coffee? Not too quickly. Cochrane Collaboration , a global network of scientists and physicians that compiles systematic reviews evaluating medical therapies, has taken a closer look at the evidence on Cerebrolysin.The question was: Does the use of Cerebrolysin after a stroke provide an advantage over standard therapy? Here the clear answer was, Cerebrolysin offers no advantage. However, Bryan Johnson refers to other animal studies and experimental approaches. Ultimately, everyone has to decide for themselves whether this is worth it.
Did you know?
In some pictures on Instagram, Bryan Johnson can be seen with painted fingernails. According to him, this is his protest against the Mormon Church, of which he was a member until he was 34 years old. There, any form of beautification of the body was considered a blasphemous sin. Painting his fingernails was part of his "religious liberation".
Bryan Johnson and Blueprint – all the power of AI
If you're wondering how Bryan Johnson decides what to try next to extend his life, you might be surprised to learn that when in doubt, he doesn't actually decide for himself. Rather, the tech millionaire believes that AI is superior to humansHe sees himself more as a test subject for artificial intelligence in order to get the best possible results from his cells. But he is no longer alone in this. Some time ago, Bryan Johnson jokingly created a profile of his dream woman. It included some absurd rules (go to bed every day at 8:30 p.m., sex only by appointment). Bryan Johnson does not have a new girlfriend (as of June 2024), but pictures of a female person with Bryan Johnson keep cropping up. DThe woman behind Blueprint is Kate Tolo, 27 years old and responsible for Blueprint’s marketing. She is also the first woman to participate in the Blueprint project and for this reason she is jokingly called Blueprint Project XX called.
Hormone therapy – not without controversy
In addition to his Besides nutritional supplements, a strict diet, a training plan and all his gadgets, there are other ways that Bryan Johnson uses to stop aging. Some of them are not without controversy.
This is how the American substitutes testosterone. Potential benefits of this therapy include improved sexual function, increased muscle mass and bone density, improved mood and well-being, and increased cognitive performance. His testosterone level is over 700 according to his website (though no unit is given).
A blind increase in the male sex hormone is not without risks. These include a possible increased rate of heart attacks, strokes and red blood cells. Bryan Johnson also takes 17-alpha-estradiol because it has been shown to prolong life in mouse studies.
Did you know?
Bryan Johnson wears a so-called Adam Sensor every night, which he uses to measure the duration of his nocturnal erections. Using shock wave therapy, he says he has been able to increase the duration to an average of 2 hours and 12 minutes per night. His goal is more than 3 hours per night.
Gene Therapy: Another Step for Bryan Johnson
For one of his most daring attempts, the American flew to Roatan, Hondurasto join a Follistatin gene therapy According to their own statements, this is Method ranks 7th among life-prolonging measures. But what is it about?
Follistatin is a protein that occurs naturally in the body and plays a role in Regulation of muscle growth playsby inhibiting myostatin. Myostatin is a protein that slows down muscle growth. Gene therapy with follistatin aims to increase the expression of this protein to increase muscle mass and potentially slow down aging.
Follistatin gene therapy involves introducing the follistatin gene into the patient's cells using a viral vector. This vector carries the gene into the cells, where it begins to produce the follistatin protein. The increased production of follistatin inhibits myostatin, which can lead to increased muscle mass and potentially improved overall physical function.
Follistatin – not without risk
Follistatin therapy is a highly experimental treatment that is not approved in Europe or the USA. As with any gene therapy, follistatin gene therapy also has potential risks and side effects:
- immune reaction: The body could respond to the viral vector carrying the gene with an immune reaction, which could lead to inflammation and other immunological problems.
- Uncontrolled muscle growth: Excessive inhibition of myostatin could lead to uncontrolled muscle growth, which could result in further health complications.
- tumor formation: There is a theoretical risk that the introduction of foreign genes could promote the growth of tumors.
- accuracy of gene integration: If the follistatin gene is integrated at unwanted locations in the genome, this could lead to genetic mutations and undesirable effects.
Bryan Johnson (and his father) have nevertheless decided to undergo therapy and he proudly presents his results on Instagram:
- Its aging rate has dropped to 0.64
- His muscle mass has grown by 7%
- And his follistatin levels in the blood were 160% higher after gene therapy
Results
Busy days, a strict vegan diet, over a hundred supplements a day, numerous anti-aging treatments, expenses in the millions – is it all worth it? Definitely, Bryan Johnson would probably say. Let's let the numbers speak for themselves:
According to its website, all blood markers in the absolute ideal range – regardless of whether it was liver values, blood sugar, kidney parameters or blood lipids. Initially, he was able to reduce his biological age by eight years (from 44 to 36).The The density of wrinkles on his skin corresponds to that of a 10-year-old, while his physical performance (measured by VO2max) the capacity of 18-year-olds corresponds. The body fat percentage is comparable to 16-year-old people and his current rate of aging (measured with Dunedin PACE) is just 0.69To put it more clearly, this means that he only "ages" 277 days per year (365 days). As a reminder: The American is currently 45 years old.
We would then never see whether all his efforts ultimately lead to eternal life. Or maybe they would?
