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Docosahexaenoic acid (DHA)

Docosahexaenoic acid (DHA)

You may have heard of docosahexaenoic acid (DHA) belongs – an essential omega-3 fatty acid, which is essential for many important functions in the body. This long-chain fatty acid plays a crucial role in the structure and function of cell membranes, especially in the brain and eyes. Your body cannot produce DHA on its own, so you must get it from food. In this article, we'll show you everything you need to know about this fatty acid, the health benefits it brings, and who can benefit from it.

What is DHA?

DHA, known as docosahexaenoic acid, is a essential omega-3 fatty acid, which consists of 22 carbon atoms and six double bonds. This chemical structure makes DHA a crucial component of cell membranes, especially in brain and retinal cells. By integrating into these membranes, DHA helps maintain cell structure and function, which is essential for your brain and eye health.

One of the special features of the docosahexaenoic acid lies in the position of the first double bondthat distinguishes omega-3 fatty acids from omega-6 fatty acids. This double bond is crucial for the functionality of omega-3 fatty acids, as it affects the structure and flexibility of the fatty acid molecules. Compared to saturated fatty acids, omega-3 fatty acids are more flexible and can be better incorporated into cell membranesThis flexibility contributes to the fluidity of the membranes and supports the transmission of signals between cells. This also explains some of the health benefits of omega-3 fatty acids, which we will explain in more detail below.

Natural occurrence of docosahexaenoic acid

You find DHA in various foods, especially in fatty fish such as salmon, mackerel, sardines and herringThese fish feed on algae, which are rich in omega-3 fatty acids and store DHA in their fatty tissue, making them a great natural source of DHA. Some types of algae contain high levels of DHA themselves, making them a suitable option for vegetarians and vegans looking to meet their DHA needs.

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Difference between DHA and EPA

You may be wondering what the difference is between DHA and eicosapentaenoic acid (EPA) Although both belong to the omega-3 fatty acids and offer similar health benefits, there are differences. DHA is especially important for brain and eye health, while EPA is known for its anti-inflammatory properties and is often used to support cardiovascular health.Would you like to learn more about the health benefits of omega-3 fatty acids If you want to know more, please read our magazine article about it.

Forms of DHA intake

There are various ways to take docosahexaenoic acid. A common method is to take dietary supplements in the form of fish oil capsules or algae oil supplements. These offer a convenient way to get a sufficient amount of DHA, especially if you limit your fish consumption or do not want to consume fish products. Another advantage is that you avoid exposure to heavy metals. Fish often contains high concentrations of harmful substances such as mercuryA prominent example of mercury poisoning is the American doctor Dr. Hyman.

Another option is to incorporate docosahexaenoic acid-rich foods into your diet. In addition to fatty fish and algae products, some other foods such as Walnuts and flaxseeds contain lower amounts of omega-3 fatty acids, including DHA. By eating these foods regularly, you can naturally increase the DHA levels in your body.

Which foods contain DHA?

The exact amounts of DHA vary, but here are some foods that are rich in DHA:

  • Salmon
  • mackerel
  • sardines
  • herring
  • algae (e.g. spirulina, chlorella)
  • walnuts
  • linseed

Effects and benefits of docosahexaenoic acid

DHA has many health benefits. It supports brain development and function, especially during pregnancy and in the early years of life. Studies show that adequate intake of docosahexaenoic acid the can improve cognitive function, strengthen memory, and reduce the risk of neurodegenerative diseases such as Alzheimer's and dementia.

DHA also plays an important role in maintaining the vision and retinal health. It is an essential component of the photoreceptors in the eyes and helps prevent age-related macular degeneration and dry eyes.

In addition, DHA anti-inflammatory properties and can reduce the risk of cardiovascular disease by regulating cholesterol levels, protecting blood vessels and inhibiting blood clotting.


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Prenatal intake of DHA

If you are pregnant or planning to become pregnant, it is important to pay attention to your diet to support the optimal development of your baby.A crucial component is the intake of docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for the development of your baby's brain and eyes.

Why is DHA important during pregnancy?

DHA plays a crucial role in development of your baby's central nervous system and retina. During the prenatal period, the supply of DHA is passed to the developing baby via the placenta. Therefore, adequate DHA intake during pregnancy can help support your child's cognitive development and vision.

How much DHA should you take during pregnancy?

The recommended intake of DHA during pregnancy varies depending on the individual needs and health of the mother. The American Pregnancy Association recommends a daily intake of at least 200-300 mg DHA during pregnancy.

Current studies on DHA

Research into the health benefits of docosahexaenoic acid is extensive. A meta-analysis of studies found that supplementation can improve cognitive function in older adults. Another study showed that adequate DHA intake during pregnancy can reduce the risk of preterm birth.

Further studies have shown that the docosahexaenoic acid can have a positive effect on mood and emotional well-being, by supporting the production of neurotransmitters such as serotonin and dopamine.

DHA and LDL levels

Some studies have found that taking DHA alone or with EPA may increase LDL cholesterol levels, particularly in people with certain lipid disorders. This may be confusing, because after all, a low LDL level is important for the health of our blood vessels, right?

Well, the answer to this question is not that simple. However, there are reasons why omega-3 fatty acids can lead to an increase in LDL cholesterol levels in some studies. For one thing, the dosage seems to play a role. In some studies, very high doses of up to 6 g per day were administered, which may have contributed to this effect.

Further Omega-3 fatty acids do not seem to increase the amount of LDL cholesterol to increase, but rather to act on the LDL receptor, which means that less LDL can be absorbed from the blood into the cells. This can cause LDL levels in the blood to rise, even though the actual production of LDL does not increase.

It is also important to note that these results were observed primarily in people who already had very high triglyceride and LDL cholesterol levels. This suggests that the effect of omega-3 fatty acids on LDL levels depends greatly on individual baseline levels and does not necessarily apply to everyone.

Conclusion

Docosahexaenoic acid (DHA) is an important omega-3 fatty acid with numerous health benefits. By consuming DHA-rich foods or using supplements, you can help improve your health and enhance your well-being. Whether you choose fish, algae, or other sources, getting enough DHA is crucial for your body to function optimally.

Literature

  • Gutiérrez, Saray et al. “Effects of Omega-3 Fatty Acids on Immune Cells.” International journal of molecular sciences 20,20 5028. 11 Oct. 2019, Link
  • “Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms.” (2014). Link
  • “Office of Dietary Supplements– Omega-3 Fatty Acids.” (2021). Link
  • “Omega-3 Supplements: In Depth.” (2021). Link
  • “Omega-3 acid ethyl esters: EMA confirms omega-3 fatty acid medicines are not effective in preventing further heart and blood vessel problems in patients who have had a heart attack.” (2018). Link
  • “Risk assessment on omega-3 fatty acids.” (2023). Link
  • “Supplements containing omega-3 fatty acids can increase the risk of atrial fibrillation in heart patients.” (2023). Link

Grafiken

The images were acquired under license from Canva.

Table of contents

Tocotrienols (vitamin E)

tocotrienols are a special form of vitamin E, which are characterized by their unique chemical structure and potential health benefits. In contrast to tocopherols, the more common forms of vitamin E, tocotrienols have shorter saturated side chains, which allows them to penetrate cell membranes more efficiently and antioxidant effects These properties make them particularly effective in protecting cells from oxidative stress and free radical damage. Studies have shown that tocotrienols can provide anti-inflammatory, neuroprotective and cardiovascular benefits, making them an important part of a health-promoting diet. Their importance for human health extends to various areas, including the prevention of chronic diseases and the promotion of healthy ageing.

Tocotrienol Effect: How do tocotrienols work in the body?

Tocotrienols are known for their potent antioxidant properties that go far beyond those of tocopherols. They work in the body by penetrating cell membranes and incorporating themselves into the lipid bilayers of cell membranes. This property allows them to act effectively against oxidative damage caused by free radicals. Free radicals are unstable molecules that can damage cells and contribute to chronic diseases and aging processes.

The antioxidant abilities of tocotrienols play an essential role in neutralizing these harmful molecules. By reducing oxidative stress, tocotrienols can protect the integrity of cell membranes and DNA, which in turn helps prevent cancer, cardiovascular disease, and neurodegenerative diseases. In addition, studies have shown that tocotrienols have anti-inflammatory effects by inhibiting the expression of pro-inflammatory cytokines. This may help reduce chronic inflammation associated with many age-related diseases.

In addition to their antioxidant and anti-inflammatory properties, tocotrienols also have a neuroprotective effectThey promote the survival of nerve cells and protect the brain from ischemic damage, which is particularly important in the prevention of strokes and other neurological diseases. In addition, tocotrienols support cardiovascular health by regulating cholesterol levels and preventing the formation of atherosclerotic plaques.

Tocotrienols vs. Tocopherols: The Difference Explained

While tocotrienols and tocopherols both belong to the vitamin E family, they differ significantly in their chemical structure and biological effects. Tocopherols have a saturated side chain, while tocotrienols have an unsaturated side chain. These structural differences give tocotrienols a greater ability to penetrate cell membranes and enter the lipid bilayer.

Another significant difference lies in their antioxidant capacities. Tocotrienols are up to 50 times more effective than tocopherols in combating lipid peroxidative damagecaused by free radicals. This makes them particularly effective in protecting cell membranes and lipoproteins from oxidative stress.

In addition, tocotrienols show a stronger effect on the Inhibition of cholesterol synthesis in the liver.This happens by suppressing the enzyme HMG-CoA reductase, which plays a key role in the cholesterol production This property makes tocotrienols a promising agent for lowering LDL cholesterol levels and promoting heart health.

In addition, tocotrienols have specific effects on cancer prevention that are not observed to the same extent with tocopherols. They can inhibit the growth of cancer cells, promote their apoptosis (programmed cell death) and suppress angiogenesis (formation of new blood vessels) in tumors.

Due to these unique mechanisms of action, tocotrienols deserve special attention in research and clinical application. Their ability to go beyond pure antioxidant effects and provide comprehensive health benefits sets them apart from tocopherols and makes them an important part of a health-promoting diet and supplementation.

Vitamin E Tocotrienols: Specific Benefits for Longevity

Tocotrienols, a lesser-known form of vitamin E, play a remarkable role in promoting health and longevity. Their unique chemical properties allow them to efficiently penetrate cell membranes and exert powerful antioxidant effects. These abilities are crucial for protecting cells from oxidative damage that can contribute to aging processes and chronic diseases. Studies have shown that tocotrienols not only reduce oxidative damage but also improve cell function and integrity, leading to a healthier and potentially longer life.

Cell Protection and Antioxidants: The Role of Tocotrienols

One of the outstanding properties of tocotrienols is their ability to act as powerful antioxidants. These substances neutralize free radicals, the unstable molecules that can damage cells and accelerate the aging process. Free radicals are created by normal metabolic processes as well as by external factors such as pollution and UV radiation. Tocotrienols protect cells by intercepting and neutralizing these harmful molecules before they can cause damage. This helps maintain cell health, reduce the risk of DNA damage and thus prevent the development of cancer and other degenerative diseasesTheir ability to penetrate the lipid bilayer of cell membranes makes tocotrienols particularly effective in protecting cell structure and function.

Anti-inflammatory properties of tocotrienols

In addition to their antioxidant abilities, tocotrienols also have powerful anti-inflammatory properties. Chronic inflammation is a known risk factor for many age-related diseases, including cardiovascular disease, diabetes, and neurodegenerative disorders. Tocotrienols exert anti-inflammatory effects by inhibiting the activity of enzymes and molecules that promote inflammatory responses. For example, they block the production of pro-inflammatory cytokines and reduce the expression of enzymes such as cyclooxygenase-2 (COX-2), which are involved in inflammatory processes. By reducing these inflammatory markers, tocotrienols help reduce the risk of chronic inflammation and related diseases. Their anti-inflammatory effects therefore not only support general health but also promote a long and healthy life.

By combining their antioxidant and anti-inflammatory effects, tocotrienols offer comprehensive benefits for longevity and healthy aging. Their ability to prevent cellular damage and reduce inflammation makes them a valuable component of a health-promoting diet and potentially also an effective supplement to promote quality of life in old age.

Tocotrienols in food: Where can you find them?

Tocotrienols are found in various plant foods, which serve as excellent sources of this valuable form of vitamin E. These foods can be easily incorporated into your daily diet to reap the health benefits of tocotrienols.

palm oil

One of the richest natural sources of tocotrienols is palm oil, particularly red palm oil. It contains high concentrations of all four forms of tocotrienols (alpha, beta, gamma and delta tocotrienol). Palm oil can be used in cooking and adds a mild flavor to dishes while also having a high heat tolerance.

rice bran oil

Rice bran oil is another oil rich in tocotrienols. It is extracted from the tough outer shell of the rice grain and is widely used in many Asian cuisines. Rice bran oil can be used for frying, baking or as an ingredient in salad dressings.

barley

Barley, a grain grown in many parts of the world, also contains tocotrienols. Barley can be prepared in soups, stews, or as a side dish. It not only provides tocotrienols, but also fiber and other important nutrients.

Oats

Similar to barley, oats also contain tocotrienols. Oatmeal for breakfast or oatmeal cookies are easy ways to incorporate oats into your diet while benefiting from their vitamin E content.

wheat germ oil

Wheat germ oil, which is extracted from the germ of the wheat grain, is another good source of tocotrienols. It can be used as a cooking oil or mixed into smoothies and dressings. Wheat germ oil is sensitive to high temperatures, so it is preferably used raw or at low temperatures.

annatto oil

Annatto oil, which is extracted from the seeds of the annatto shrub, is particularly rich in delta and gamma tocotrienols. It is often used as a natural coloring and flavoring in foods and can also be used as a cooking oil.

nuts and seeds

Some nuts and seeds, such as almonds, hazelnuts and sesame seeds, also contain smaller amounts of tocotrienols along with other forms of vitamin E. They can be eaten as a snack or used in various dishes.

Green leafy vegetables

Certain green leafy vegetables, such as spinach and kale, also contain tocotrienols. These vegetables can be prepared in salads, smoothies, or as a side dish to add extra vitamin E content to the diet.

whole grain products

Whole grains such as whole wheat bread, whole wheat pasta and brown rice also contain tocotrienols. Eating whole grains instead of refined grain products not only improves the absorption of tocotrienols but also provides additional fiber and nutrients.

What is Vitamin E for? General Health Benefits

Vitamin E is an essential fat-soluble antioxidant that offers a variety of health benefits.It plays a central role in various biological processes and contributes significantly to maintaining health.

skin health

Vitamin E is widely known for its beneficial effects on the skin. As a powerful antioxidant, it protects skin cells from oxidative stress and free radical damage caused by UV radiation and pollution. It can help slow skin aging, reduce wrinkles, and improve skin elasticity. Vitamin E is often used in skin care products to moisturize and promote the healing of scars and wounds.

immune function

Another significant benefit of vitamin E is its role in supporting the immune system. It strengthens the immune response by improving the function of immune cells. Studies have shown that adequate vitamin E can reduce the risk of infections, especially in older adults. It supports the formation of T lymphocytes and the production of antibodies, which are important for fighting off pathogens.

cardiovascular health

Vitamin E plays an important role in maintaining cardiovascular health. It helps prevent the oxidation of LDL cholesterol (the "bad" cholesterol), which in turn reduces the formation of plaque in the arteries and lowers the risk of atherosclerosis and heart disease. In addition, vitamin E can improve blood vessel function and reduce platelet aggregation, thus minimizing the risk of blood clots.

eye health

Vitamin E also has beneficial effects on eye health. It can reduce the risk of age-related macular degeneration (AMD) and cataracts, which can lead to visual impairment and blindness. As an antioxidant, it protects the cells of the lens and retina from oxidative stress and helps maintain good vision.

brain health

The neuroprotective properties of vitamin E may help protect against neurodegenerative diseases such as Alzheimer's and Parkinson's. Vitamin E protects nerve cells from oxidative damage and inflammation, which can lead to degeneration of the nervous system. Studies have shown that adequate vitamin E intake can improve cognitive function and memory in older people.

Hormonal Balance

Vitamin E has a positive effect on hormonal balance, especially in women. It can relieve symptoms of premenstrual syndrome (PMS) by reducing the pain and discomfort during the menstrual cycle. Vitamin E can also help women going through menopause to reduce hot flashes and other symptoms.

cell protection and DNA repair

As an antioxidant, vitamin E plays an essential role in protecting cell membranes and DNA from oxidative damage. It helps maintain the integrity of cell structures and contributes to the repair of damaged DNA. This supports overall cellular health and may reduce the risk of cancer and other degenerative diseases.

muscle regeneration and athlete health

For athletes and physically active people, vitamin E may also be beneficial. It supports muscle recovery after intense exercise by reducing muscle inflammation and damage. Vitamin E may improve endurance and performance by optimizing oxygen supply to muscles and reducing the formation of lactic acid.

wound healing

Vitamin E promotes the healing of wounds and scars by accelerating the regeneration of skin cells and reducing inflammation. It can be used both internally through supplements and externally through creams and oils to support the healing process.

Side Effects of Vitamin E: What You Should Know

Vitamin E is generally considered safe and healthy known, however, side effects can occur both naturally and when taken as a supplement. These can vary depending on the dosage and individual sensitivity. Here are some of the most important points to consider:

Possible side effects at high doses

At very high doses, vitamin E can be toxic. An overdose, especially from dietary supplements, can lead to various health problems. The most common side effects include:

  • gastrointestinal problems: High doses of vitamin E can cause nausea, diarrhea, abdominal cramps and general gastrointestinal discomfort.
  • bleeding tendency: Vitamin E has blood-thinning properties, so an overdose may increase the risk of bleeding. This is especially important for people taking blood thinners or suffering from bleeding disorders.
  • headaches and dizziness: Some people report headaches and dizziness when taking high doses of vitamin E.
  • muscle weakness and fatigue: In rare cases, an overdose may cause muscle weakness and general tiredness.

interactions with medications

Vitamin E may interact with certain medications, especially blood thinners such as warfarin and aspirin. These interactions can further increase the risk of bleeding. Also, when taking chemotherapy drugs, vitamin E can interfere with the effectiveness of the treatment. It is therefore important to consult a doctor before taking vitamin E supplements if you are taking regular medications.

Safety in natural intake

The recording of Vitamin E through diet is considered safe and is associated with a lower risk of side effects. Foods such as nuts, seeds, vegetable oils, and green leafy vegetables provide vitamin E in amounts that do not normally cause adverse effects.

Tocotrienol side effects: Are there any risks?

Tocotrienols, a special form of vitamin E, also have numerous health benefits but can have side effects if used improperly.

Possible side effects of tocotrienols

Although tocotrienols are generally well tolerated, they can cause side effects in high doses or in sensitive individuals. Possible side effects include:

  • Gastrointestinal complaints: Similar to general vitamin E, high doses of tocotrienols can cause gastrointestinal problems such as nausea, diarrhea, and abdominal pain.
  • headaches and dizziness: Headaches and dizziness can also occur as side effects, especially at higher doses.
  • risk of bleeding: Due to their blood-thinning properties, tocotrienols may increase the risk of bleeding, especially when taken at the same time as anticoagulants or in people with bleeding disorders.

Vitamin E Weight Gain: Truth or Myth?

Vitamin E is known for its antioxidant properties and numerous health benefits, but there is some misconception about whether it can contribute to weight gain.

Scientific findings

There is no conclusive scientific evidence that vitamin E directly contributes to weight gain. Vitamin E is a fat-soluble vitamin found primarily in vegetable oils, nuts, and seeds. These foods are high in calories, which may have led to confusion.

  • Calorie content of vitamin E-rich foods: Many foods rich in vitamin E also contain high amounts of fat, such as nuts and vegetable oils. Eating large amounts of these foods can lead to increased calorie intake, which could theoretically contribute to weight gain. In this case, however, it is not the vitamin E itself but the increased calorie consumption that affects weight.
  • Functions of Vitamin E in the Body: Vitamin E plays an important role as an antioxidant and supports several functions in the body, including cellular health and the immune system. However, there is no evidence that vitamin E affects metabolism in a way that directly leads to weight gain.

studies and research results

Several studies have attempted to examine the relationship between vitamin E and weight gain, but without clear evidence of a direct link:

  • Weight Control and Antioxidants: Some studies have shown that antioxidants, including vitamin E, may play a role in regulating metabolism and reducing inflammation. This could theoretically contribute to better weight control, especially by improving overall health and well-being.
  • nutritional studies: Dietary studies examining the consumption of vitamin E-rich foods have found no significant association between vitamin E and weight gain. Rather, a balanced diet rich in nutrients and low in processed foods appears to regulate body weight naturally.

The idea that vitamin E causes weight gain is largely a myth. There is no scientific evidence that vitamin E directly increases body weight. Instead, the misconception may be due to the high calorie content of vitamin E-rich foods. A balanced diet and calorie-conscious use are crucial for weight management. Vitamin E plays an important role in overall health, but it should be consumed as part of a balanced and nutrient-rich diet.

How much vitamin E per day? Recommendations for the daily dose

Vitamin E is an essential fat-soluble antioxidant necessary for maintaining good health. Daily intake of vitamin E varies depending on age group, gender and specific health conditions.Here are the general recommendations for daily vitamin E intake, based on scientific guidelines and current research.

Recommended daily dose

The recommended daily allowance (RDA) of vitamin E is measured in milligrams (mg) of alpha-tocopherol, the most abundant form of vitamin E in the body. The RDA was established by the US National Institutes of Health (NIH).

  • infants
  • 0-6 months: 4 mg per day
  • 7-12 months: 5 mg per day
  • Children
  • 1-3 years: 6 mg per day
  • 4-8 years: 7 mg per day
  • 9-13 years: 11 mg per day
  • adolescents and adults
  • Men aged 14 and over: 15 mg per day
  • Women over 14 years: 15 mg per day

upper limit of safe intake

The tolerable upper intake level (UL) defines the highest amount of vitamin E that is unlikely to have adverse health effects when taken long-term. These values ​​were also established by the NIH:

  • Children
  • 1-3 years: 200 mg per day
  • 4-8 years: 300 mg per day
  • 9-13 years: 600 mg per day
  • adolescents and adults
  • From 14 years: 1000 mg per day

These upper limits apply mainly to vitamin E from dietary supplements and fortified foods, since high doses from natural foods are rarely achieved.

Sources of Vitamin E

Vitamin E is found in a variety of foods and can be easily obtained through the daily diet.

  • nuts and seeds: almonds, sunflower seeds, hazelnuts
  • Vegetable oils: wheat germ oil, sunflower oil, safflower oil, olive oil
  • Green leafy vegetables: spinach, kale
  • whole grain products: whole grain bread, brown rice
  • fruit and vegetables: Avocados, tomatoes, sweet potatoes

Daily intake of vitamin E is crucial for maintaining good health and can be easily achieved through a balanced diet. Recommended daily doses vary according to age group and specific conditions. Be sure to meet your vitamin E intake both from natural foods and, if necessary, from supplements, and avoid overdoses by respecting the established upper limits.

Conclusion on Tocotrienols & Vitamin E

Tocotrienols, a special form of vitamin E, have gained increasing attention in recent years due to their unique health benefits. They are structurally and functionally distinct from the more well-known tocopherols and offer a wide range of potential health benefits.

Tocotrienols are a valuable component of vitamin E with a variety of health benefits. Their powerful antioxidant and anti-inflammatory properties make them an important nutrient for supporting cardiovascular health, neurological function, skin health, and possibly even cancer prevention.By following safe intake guidelines and favoring natural sources, tocotrienols can be effectively integrated into a healthy diet to fully exploit their beneficial effects.

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Folic acid (vitamin B9)

What is folic acid?

folic acid, also known as vitamin B9, is a water-soluble vitamin that belongs to the B vitamins. Chemically, folic acid consists of a pteridine ring, a para-aminobenzoic acid (PABA) and a glutamic acid. This structure allows the vitamin to play an essential role in various biochemical reactions in the body.

Folic acid is essential for numerous vital processes in the human body. It is involved in DNA synthesis and repair, thereby supporting cell division and growth. It also plays an important role in the formation of red blood cells, which is crucial for oxygen transport in the blood. Adequate folic acid levels are therefore particularly important for pregnant women to prevent malformations in the fetus, as well as for all people to maintain good health and longevity.

Why is folic acid important?

Folic acid, an essential B vitamin (vitamin B9), is of great importance for the human body and fulfills several basic functions:

DNA synthesis and cell division

Folic acid plays a central role in DNA synthesis and repair. It is involved in the formation of nucleotides, the building blocks of DNA. This is especially important during periods of rapid growth such as pregnancy, childhood and puberty, as these are times when there is increased cell division and proliferation.

blood formation

Another important aspect of folic acid is its involvement in blood formation. It promotes the production and maturation of red blood cells in the bone marrow. A deficiency in folic acid can lead to a form of anemia known as megaloblastic anemia. This condition is characterized by large, immature red blood cells that cannot carry oxygen effectively.

amino acid metabolism

Folic acid is also involved in amino acid metabolism, especially in Conversion of homocysteine ​​to methionine. Increased homocysteine ​​levels in the blood are associated with a higher risk of cardiovascular disease. By supporting the homocysteine ​​degradation Folic acid contributes to heart health.

nervous system

Folic acid plays a supportive role in the nervous system by promoting the synthesis of neurotransmitters, which are necessary for signal transmission between nerve cells. Adequate levels of folic acid can therefore help maintain good cognitive function and mental health.

Folic Acid Deficiency: Causes and Effects

Insufficient dietary intake

One of the most common causes of folic acid deficiency is inadequate intake through food. People who do not eat a balanced diet or who eat little fruit, vegetables and whole grain products are particularly at risk.

Increased demand

Certain phases of life and conditions such as Pregnancy, breastfeeding, puberty and illnesses can increase the need for folic acid. For example, pregnant women need a higher amount of folic acid to support the growth of the fetus.

diseases of the digestive tract

Diseases that affect the absorption of nutrients in the intestine, such as celiac disease, Crohn's disease or inflammatory bowel disease, can lead to a folic acid deficiency. Surgical interventions on the digestive tract can also negatively affect the absorption of folic acid.

alcohol abuse

Excessive alcohol consumption can significantly impair the absorption and metabolism of folic acid. Alcohol interferes with the conversion of folic acid into its active form and increases its excretion via the kidneys.

Drug influences

Certain medications such as anticonvulsants (used to treat epilepsy), methotrexate (a cancer drug), and some antibiotics can interfere with how the body absorbs or uses folic acid.

Effects of a folic acid deficiency

Megaloblastic anemia

Megaloblastic anemia is a common consequence of folic acid deficiency. This type of anemia is characterized by the production of abnormally large and immature red blood cells that cannot perform their function properly. Symptoms include fatigue, weakness, shortness of breath, and pale skin.

Cognitive impairments

Low folic acid levels are associated with cognitive impairment and an increased risk of dementia. A deficiency can negatively affect mental performance and memory, particularly in older people.

cardiovascular diseases

Elevated levels of homocysteine ​​in the blood, caused by a folic acid deficiency, are a risk factor for cardiovascular disease. Homocysteine ​​can damage the artery walls and contribute to the formation of blood clots.

depression and mood swings

There is evidence that folic acid deficiency may also be linked to mental health problems such as depression and mood swings. Folic acid plays a role in the synthesis of neurotransmitters that regulate mood.

Folic Acid and Longevity

The importance of folic acid for longevity is increasingly supported by scientific studies. Folic acid is an essential B vitamin, which plays a central role in numerous biological processes that are crucial for health and longevity.

One of the most important functions of folic acid is its involvement in DNA synthesis and repair. Studies show that adequate levels of folic acid help minimize genetic damage and maintain cell integrity. This is especially important because DNA damage and malfunctions in cell division are associated with the aging process and the development of diseases such as cancer.

Folic acid also helps break down homocysteine, an amino acid that can be harmful to blood vessels in high concentrations. Elevated homocysteine ​​levels are associated with a higher risk of cardiovascular disease. Studies suggest that folic acid supplementation may reduce the risk of such diseases by lowering homocysteine ​​levels and thus promoting heart health.

Low folate levels have also been linked to cognitive impairment and an increased risk of neurodegenerative diseases such as Alzheimer's. Research has shown that adequate folate intake can improve cognitive performance and protect the brain as we age.

In addition, folic acid potentially anti-inflammatory properties, which can contribute to overall health and longevity. Chronic inflammation is a known risk factor for many age-related diseases. By reducing inflammatory markers, folic acid can help reduce the risk of such diseases and improve the quality of life in old age.

Folic Acid and Weight Loss

The role of folic acid in weight loss is a topic that is attracting increasing interest in the scientific community and among health-conscious individuals. While folic acid is primarily known for its importance in DNA synthesis, cell division and blood formation, there is some evidence that it may also have an indirect effect on body weight.

Folic acid plays a central role in metabolism, particularly in amino acid and nucleotide metabolism. A well-functioning metabolism is crucial for efficient energy production and use in the body. Some studies suggest that optimal folic acid levels can support metabolism, which in turn could lead to better energy utilization and possibly also facilitate weight control.

Another aspect being investigated is the Relationship between folic acid and homocysteine ​​levels. High homocysteine ​​levels are associated with an increased risk of cardiovascular disease. Since folic acid helps lower homocysteine ​​levels, it may indirectly contribute to heart health. A healthy cardiovascular system is important for physical activity and endurance, which in turn can be helpful in weight loss.

There is also evidence that folic acid insulin sensitivity Improved insulin sensitivity means the body can more efficiently transport glucose from the bloodstream into cells, where it is used as energy or stored. This could help prevent blood sugar spikes and reduce the risk of type 2 diabetes, which may also have a positive effect on weight control. Read more about this in our article on insulin resistance.

An often overlooked factor in weight loss is mental health. Folic acid is involved in the synthesis of neurotransmitters such as serotonin, which regulate mood. A stable mood and low tendency toward depression can reduce emotional eating and thus support weight loss.

How much folic acid per day?

The recommended daily intake of folic acid varies depending on age, gender and life situation. To optimize health and avoid deficiencies, health authorities have established specific recommendations for daily folic acid intake.

The recommended daily dose of folic acid for adults is 400 micrograms (µg). This amount is sufficient to meet the needs of most people and ensure the normal functioning of the body. However, pregnant women have an increased need for folic acidto support the growth and development of the fetus and reduce the risk of neural tube defects. Therefore, they are recommended to receive a daily intake of 600 µg is recommended. Breastfeeding women should take about 500 µg per day to meet both their own needs and those of their child.

Children need different amounts of folic acid depending on their age. For infants up to six months, the recommended amount is 65 µg per day. For infants between seven and twelve months, the dose increases to 80 µg daily. Children aged one to three years should receive 150 µg per day, while four to eight-year-olds need 200 µg. Older children and adolescents need higher levels: nine to 13-year-olds should consume 300 µg per day, while adolescents aged 14 and over need the same dose as adults, namely 400 µg.

Too Much Folic Acid: Risks and Side Effects

While folic acid is an essential vitamin for numerous bodily functions, excessive intake can also pose health risks and side effects. It is important to keep a balance and not exceed the recommended daily intake unless specifically prescribed by a doctor.

masking a vitamin B12 deficiency

One of the most well-known disadvantages of excessive folic acid intake is the possibility to mask a vitamin B12 deficiency. Folic acid may mask the symptoms of megaloblastic anemia caused by B12 deficiency. This causes the B12 deficiency to go undetected and the underlying neurological damage to progress. This damage can have irreversible consequences, such as nerve damage and cognitive impairment.

impairment of the immune system

Excessive folic acid intake could impair the immune system. Some research has shown that too much folic acid can reduce the activity of natural killer cells, which play a key role in the immune system by attacking virus-infected cells and tumor cells.

Gastrointestinal complaints

High doses of folic acid can cause gastrointestinal problems such as nausea, bloating and abdominal pain. Although these side effects are usually mild, they can be unpleasant and affect the quality of life in sensitive people.

sleep disorders and behavioral problems

There is some evidence that an overdose of folic acid can cause sleep disturbances and behavioral problems such as irritability and hyperactivity in some people. This is particularly important in children, who may be more sensitive to high doses of folic acid.

Foods with folic acid

Folic acid, also known as vitamin B9, is an essential vitamin found in many foods. Here is a detailed list of foods that are particularly rich in folic acid, as well as tips for incorporating these foods into your daily diet.

green leafy vegetables

  • spinach: One of the best natural sources of folic acid. One cup of cooked spinach contains about 263 mcg of folic acid.
  • kale: Contains about 85 µg of folic acid per cup.
  • romaine lettuce: One cup contains about 64 µg of folic acid.

legumes

  • lenses: Half a cup of cooked lentils contains about 179 µg of folate.
  • chickpeas: Contains about 141 µg of folic acid per half cup.
  • black beans: Half a cup provides about 128 µg of folic acid.

whole grain products

  • Fortified bread and cereals: Many breads and breakfast cereals are fortified with folic acid and can contain up to 400 µg of folic acid per serving.
  • quinoa: One cup of cooked quinoa contains about 78 µg of folate.

fruit

  • oranges: A medium-sized orange contains about 40 µg of folic acid.
  • papaya: One cup of diced papaya provides about 53 µg of folate.
  • bananas: A medium-sized banana contains about 24 µg of folic acid.

nuts and seeds

  • sunflower seeds: A quarter cup contains about 82 µg of folic acid.
  • linseed: Two tablespoons provide about 54 µg of folic acid.

Additional sources

  • eggs: One large egg contains about 22 µg of folic acid.
  • liver: Chicken or beef liver are extremely rich in folate; 100 grams of beef liver contains about 212 µg of folic acid.
  • avocado: Half an avocado provides about 59 µg of folic acid.

When should you take folic acid?

The optimal time to take folic acid may vary depending on individual needs and health goals, but there are some general recommendations that can help maximize the effectiveness of folic acid intake.

In the morning with breakfast

A common recommendation is to take folic acid in the morning with breakfast. This has several advantages:

  • Better absorption: Taking folic acid with a meal containing other vitamins and minerals may improve absorption. Folic acid is best absorbed in a slightly acidic environment, which can be aided by foods such as fruit and whole grains.
  • regularity: Breakfast is a meal that many people eat regularly. Taking supplements at the same time each day helps establish a routine and ensure consistency.

Spread throughout the day

For individuals who require higher doses of folic acid, such as pregnant women or people with certain health conditions, it may be beneficial to spread the dose throughout the day. This can help keep blood folate levels stable and maximize bioavailability.

  • Multiple daily intake: Divide the daily dose into two or three smaller doses taken with main meals. This can be especially useful if you are using supplements with high dosages.

Before going to bed

Some people prefer to take folic acid before bed, especially if they take other supplements or medications that must be taken in the morning.

  • avoiding interactions: Taking folic acid in the evening may help avoid possible interactions with other supplements or medications taken in the morning.

Important instructions

  • Water: Always take folic acid with a glass of water to aid absorption and make it easier to take.
  • dietary supplements and medications: If you are taking other supplements or medications, talk to your doctor or pharmacist about the best time to take folic acid to avoid interactions.
  • consistency: Regardless of the time chosen, it is important to take folic acid at the same time every day to ensure a consistent supply.

Conclusion

Regular intake of adequate amounts of folic acid is crucial for maintaining good health and can make a significant contribution to a long and healthy life. Folic acid supports essential body functions, promotes cardiovascular health, supports mental performance and contributes to skin and hair health. A conscious diet, complemented by necessary supplements, ensures that the body is optimally supplied with this important vitamin. By ensuring that we have sufficient folic acid intake, we can improve our overall health and lay the foundation for a longer, healthier life.

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