Many know hyaluron, or hyaluronic acid, from plastic surgery, where the substance has long been used as a "wrinkle filler" for the skin. The molecule occurs naturally in our body – we can even produce it ourselves to a certain extent. However, with age, the content of hyaluron in our body decreases, leading to reduced elasticity of the skin. Some studies have shown that regular intake of hyaluron can reduce wrinkle depth. Learn more about the fascinating molecule hyaluron and what benefits it brings to you.
Occurrence of hyaluron
The name hyaluronic acid is derived from its discoverer Karl Meyer.In the 1930s, this substance was first isolated from the vitreous body of cow eyes, consisting of many disaccharides and uronic acids. The ancient Greek word for glass is "hyalos," and thus he named the newly discovered substance Hyaluronic Acid. Hyaluron is the abbreviation of the word. In our body, there are a total of about 15 grams of Hyaluronic Acid, distributed among other places in our joints, connective tissue, the vitreous body of the eye, and in the skin. About half of the total hyaluron is found in the skin, both in the upper epidermis and in the deeper dermis.
Here are a few more impressive numbers:
– The hyaluronic acid content in the skin of a 75-year-old is approximately only a quarter compared to that of a 19-year-old person!
– Your body synthesizes about 5g of hyaluronic acid per day, with the same amount being broken down. So approximately one third of the total amount of hyaluron in your body is broken down and rebuilt daily.
Hyaluronic acid (hyaluron) is very commonly used in plastic surgery.
What does hyaluronic acid do?
To understand the role of hyaluron in our body, we need to take a closer look at the molecular structure. Hyaluronic acid consists of a chain of disaccharides, known as disaccharides.The disaccharide molecules are modified glucose building blocks that bear the complicated names D-glucuronic acid and N-acetyl-D-glucosamine. Due to these modifications, the individual disaccharides can be linked together like a chain. This is chemically referred to as polymers. This structure makes it possible, that hyaluronic acid can bind a lot of water.
Depending on how many disaccharides are linked together, one obtains molecules of varying weights. A rough distinction is made between light, also known as low molecular weight hyaluronic acid (NMW) and heavy, so-called high molecular weight hyaluronic acid (HMW).
This distinction is important, as the two molecules possess differing properties.
High Molecular Weight Hyaluronic Acid (HMW)
High molecular weight hyaluronic acid is referred to from a weight of 106 Dalton. This is approximately 100 kilodaltons (kDA). High molecular weight hyaluronic acid, as found in MOLEQLAR Hyaluronic Acid , is found in joint cartilage and synovial fluid as a "lubricant." Additionally, some studies have shown that it has a positive effect on wound healing. It supports connective tissue and reduces inflammation in the body through interaction with surface molecules of our defense cells.
Furthermore, it has been demonstrated in several double-blind, placebo-controlled studies (highest evidence) that after 28 days of oral intake of high molecular weight hyaluronic acid, the depth of wrinkles was significantly reduced.
One gram of hyaluronic acid can bind approximately 6 liters of water. The vitreous body of our eye consists of about 98% water. The remaining two percent are hyaluron and collagen fibers.
Low molecular weight hyaluron (NMW)
Low molecular weight hyaluron has also been shown in some studies to reduce wrinkle depth – however, it was not as effective as high molecular weight hyaluron. Pro-inflammatory (inflammation-promoting) signals were rather observed under low molecular weight hyaluron.
In certain diseases, bronchial asthma, pulmonary fibrosis, and arterial hypertension, the body's own high molecular weight hyaluron is converted into low molecular weight hyaluron. Studies have shown that this shift to more NMW promotes an increased inflammatory response.
Hyaluron in Science and Research
Hyaluron is used in many areas of medicine due to its unique biological and chemical properties. Here are some examples:
- as a "carrier substance" in pharmaceuticals.
- as a topical application in wound healing
- in eye surgery to protect the eye
- as a "lubricant" in the joint
- as an ingredient in nasal sprays to reduce dryness
There are many other areas where hyaluron is used. One area of research is the use of hyaluronic acid as a "carrier" molecule for cancer drugs. It has been shown that some tumors overexpress the CD44 receptor. Hyaluronic acid can bind to this receptor, making it an interesting molecule for developing targeted therapy approaches.
Did you know?
The hyaluronic acid is a very versatile molecule that plays an important role in aging research. It likely positively affects some of the Hallmarks of Aging . This is one of the reasons why we also rely on hyaluron as an effective ingredient in our innovative MoleQlar ONE .
Hyaluron is an ideal lubricant in our joints due to its water-binding capacities.
How do we absorb hyaluronic acid?
Hyaluron is – as mentioned before – a quite large molecule. Too large to be fully absorbed by our intestines.For a long time, it was believed that an oral substitution of hyaluronic acid would be ineffective, as the molecule is broken down into smaller pieces in our intestines.
However, this assumption has been disproven. Although hyaluronic acid is broken down into smaller fragments in our intestines, these fragments find their way into our connective tissue and activate the same signaling pathways as hyaluronic acid. Additionally, high molecular weight hyaluronic acid is absorbed as a complete molecule through our lymphatic system. In a larger review, the results of several studies were compiled. Here, some results emerged. First, researchers found that after at least four weeks of daily intake of high molecular weight hyaluronic acid, wrinkles were reduced and skin moisture improved.Even more exciting is that a study has shown that orally ingested high molecular weight hyaluron is deposited in the connective tissue.
In a study , 60 patients with knee osteoarthritis were given 200mg of hyaluron orally for 12 months. The other group received corn starch. Both groups followed a comparable exercise program. After 12 months, the hyaluron group benefited. They showed a greater reduction in pain, with particularly those under 70 years old benefiting from daily intake.
Hyaluron typically has a very viscous consistency in skincare products.
Hyaluron in the cosmetics industry
Hyaluron has long been known as an additive in creams, serums, or gels in the cosmetics industry.
Our skin owes its elasticity and firmness to the connective tissue. The main components are collagen, elastin, and hyaluronic acid. Due to its water-binding ability, hyaluronic acid is responsible for the moisture content and thus indirectly for the firmness of our skin.
As our body produces less hyaluronic acid with age and the skin loses moisture, there is a loss of volume. We see this when our skin develops wrinkles. Often, our skin is a reflection of our "felt" age. Our largest organ is visible to everyone around us, which is why we want to avoid skin aging as much as possible.
Hyaluronic gels promise to compensate for this loss of moisture. However, the research on this is not conclusive. It is very likely that hyaluronic acid applied to the skin cannot penetrate deeply enough into the skin. It rather binds water on the skin. The only option, besides oral supplementation, is the injection of hyaluronic acid into the skin. Depending on the hyaluronic acid used, the effect lasts from 6 to 24 months.
Collagen is the most abundant protein in our skin. As we age, our body reduces collagen synthesis, similar to hyaluronic acid. This also contributes to skin aging.
Glycine, an amino acidthat we obtain from food, can, according to some studies, promote collagen synthesis and thus, together with hyaluronic acid, prevent premature skin aging.
Glycine and hyaluronic acid work together on two important aging processes in the skin and can have positive effects on your skin health. Both molecules are found together in MOLEQLAR Hyaluron . Additionally, glycine is also available as pure glycine powder.
With the Skin Glow Essentials Bundle, you combine the power of all three molecules: hyaluronic acid, collagen, and glycine for a skin-close synergy.
Hyaluronic acid for different skin types: What you should know
There are different types of hyaluronic acid products that are tailored to different skin types.
Dry Skin: Hyaluronic acid can help lock in moisture in the skin, alleviating dryness and tightness. It is particularly effective when applied to damp skin and sealed with a moisturizing cream.
Oily Skin: Even people with oily skin can benefit from hyaluronic acid, as it provides hydration without clogging pores or leaving an oily film on the skin.
Sensitive Skin: Hyaluronic acid is very gentle on the skin and can therefore be used on sensitive skin as well. It can help strengthen the skin barrier and minimize irritation.
“Aging” skin: As we age, the natural hyaluronic acid content of the skin decreases, which can lead to dryness and the formation of wrinkles. Hyaluronic acid products can help minimize these signs of skin aging.
Hyaluronic acid in skincare: this is the current state of science
Hyaluronic acid is a natural component of the body that is found in many skincare products. It is known for its ability to bind water, thereby hydrating and firming the skin.
Hyaluronic acid can bind moisture: Hyaluronic acid has the ability to bind up to 1000 times its own weight in water. This makes it an excellent moisturizer and helps keep the skin hydrated and plump.
Hyaluronic acid can strengthen the skin barrier: Due to its moisturizing properties, hyaluronic acid can help strengthen the skin barrier, contributing to healthy, resilient skin.
Hyaluronic acid can minimize signs of skin aging: As we age, the natural hyaluronic acid content of the skin decreases, which can lead to dryness and wrinkle formation. Topical applications of hyaluronic acid can help reduce these signs of skin aging.
Hyaluronic acid is safe for most skin types: Hyaluronic acid is very gentle on the skin and is generally well tolerated, making it a good option for all skin types, including sensitive skin.
Hyaluronic acid is one of the most effective moisturizers.It can hold 1000 times its own weight in water
Hyaluronic Acid vs. Other Moisturizers: A Comparison
Compared to other moisturizing ingredients Hyaluronic acid offers more intense and longer-lasting hydration. It draws water into the skin and retains it there, helping to keep the skin plump and hydrated. Additionally, hyaluronic acid is also very gentle on the skin and is generally well tolerated, making it a good option for all skin types.
Other commonly used moisturizing ingredients include glycerin, urea, aloe vera, and various oils. Glycerin is another highly hygroscopic active ingredient that draws water into the skin and helps to keep it there.Urea is known for its ability to smooth the skin and remove dead skin cells while simultaneously providing moisture.
Aloe Vera is known for its soothing and moisturizing properties and can be particularly beneficial for dry or irritated skin. Oils, such as jojoba oil or argan oil, can also provide moisture and help strengthen the skin barrier.
How to incorporate hyaluronic acid into your daily skincare routine
Hyaluronic acid is a powerful moisturizer and can easily be integrated into your daily skincare routine.
Thoroughly cleanse your face: Before applying hyaluronic acid, it is important to cleanse your face to remove excess oil and dirt.This allows for better absorption of hyaluronic acid by the skin.
Apply to damp skin: Hyaluronic acid binds moisture and draws it into the skin. Therefore, it is best to apply hyaluronic acid to damp skin to maximize its moisturizing properties.
Seal with a moisturizer: After applying hyaluronic acid, you should always apply a moisturizing cream or lotion. This helps to lock in moisture and enhance the effectiveness of the hyaluronic acid.
Regular use: For optimal results, you should use hyaluronic acid products regularly. Many experts recommend using them twice a day, once in the morning and once in the evening.
Combine with other ingredients: Hyaluronic acid can be well combined with other ingredients in your skincare routine. For example, the combination of hyaluronic acid with vitamin C can help, improve the brightness and radiance of the skin.
We at MoleQlar offer pure, vegan hyaluronic acid in capsule form and of the highest quality.
Hyaluronic acid in food
Hyaluronic acid is found in both animal and plant foods. In animal foods, hyaluronic acid is mainly found in cartilage tissue or in broths made from animal bones.Other sources are:
- Fish, such as mackerel or sea bream
- Potatoes
- Leafy green vegetables
- Bananas
- Almonds
- Sweet potatoes
- Cashew nuts
- Tofu
The exact amounts of hyaluronic acid in foods are not well researched. A healthy, balanced diet, along with adequate supplementation, can contribute to an increased intake of hyaluronic acid.
Hyaluron and L-Glycine form a skin-close synergy in the MoleQlar product.
How is hyaluron produced?
In the past, hyaluronic acid had to be painstakingly extracted from bovine eyes or rooster combs. Since this method is not very sustainable, researchers have come up with other methods.
Nowadays, hyaluronic acid is produced by genetically modified bacteria. In large fermentation plants, pure, vegan hyaluron can be obtained. Due to the various filtration processes, the risk of allergies is also lower than with animal products. The end product is also completely free of genetic engineering, as the bacteria are completely removed.
This pure, vegan form of hyaluronic acid can also be ordered from us . Together with glycine, hyaluron fights on the front lines of your metabolism and skin health!
Summary
Hyaluronic acid is an important component of our body. However, as we age, we gradually lose the ability to produce hyaluron.There is a reduced skin elasticity, wrinkles increase, and our "lubricant" in the joints decreases, leading to more pain.
The supplementation with hyaluronic acid has been rated as safe in many studies. Daily intake of hyaluronic acid can help your skin have fewer wrinkles and reduce inflammation in the body. Thus, you support, among other things, your largest organ, the skin, against premature aging.
