Collagen is one of the most abundant proteins in our bodyIt makes up a large part of our connective tissue, which consists of long, fibrous molecules. Depending on its composition, collagen can have different properties. For example, collagen gives our skin structure and collagen built into tendons provides greater tensile strength.
As we age, the collagen content decreasesThe consequences: our skin becomes brittle and wrinkles, while our tendons are no longer as resilient as they once were. You can find out what the reason is and how you can partially stop this decline here.
Collagen in our body: The structural basis
With a share of almost 30%, collagen is by far the most common protein in our body. It is formed by specialized cells called fibroblasts. Three amino acids are strung together until long, fiber-like molecules are formed. It always starts with Glycine.
The long, thread-like molecules are subsequently combined to form a so-called triple helix Imagine a braided plait, this is what the collagen structures look like. Finally, these interwoven molecules first deposit in smaller packages to form “fibrils” together, which in turn then, due to the large number, the collagen fibers form.
Did you know? Two important enzymes in collagen synthesis, prolyl hydroxylase and lysyl hydroxylase need both vitamin C as a cofactorWithout enough vitamin C, these enzymes cannot attach the important hydroxyl groups that are later necessary for the cross-links. To put it simply, the resulting collagen would be significantly more unstable.
Low molecular weight collagen peptides in powder form are one way to prevent age-related decline in collagen levels.
The framework for healthy and firm skin
The collagen in our skin is constantly being regenerated by fibroblasts. The large collagen fibers serve as a kind of tight net, in which the various other molecules are arranged. Too much UV light and age lead to a lower collagen content over time. The result: our skin develops wrinkles. But why is that?
As always, there is no simple answer to a rather complex question. Researchers know several factors. One is the UV radiation, which damages our skin in two ways: Firstly, the activity of the fibroblasts is inhibited, so that less collagen is formed and secondly, there is increased damage to the skin, which activates so-called collagenases. These enzymes "digest" actually functional collagen.
With age, the composition of collagen fibers also changesThey become thinner, so that our framework becomes increasingly fragile. The exact reason for this is not yet fully understood. One hypothesis is that as we age, the blood supply, particularly through the tiny vessels, deteriorates, thus impairing collagen formation.
Interestingly, UV damage appears to be independent.This means that we already have an effective starting point to prevent premature skin aging: Regular application of a sunscreen containing UV protection (preferably 50+) can effectively prevent skin aging.
Did you know? In addition to collagen, hyaluronic acid is extremely important for healthy skin and healthy joints. While collagen is insoluble in water and scores above all for its stability and firmness, hyaluronic acid binds extraordinarily large amounts of water and thus provides volumeHowever, the hyaluronic acid content in our skin decreases with age, making it appear less “full”. Some studies have shown that oral supplementation with high-molecular hyaluronic acid the depth of wrinkles can be reduced. More information: what is hyaluronic acid?
Collagen and hyaluronic acid work together to increase skin elasticity and health as we age.
Fewer wrinkles through collagen?
With both hyaluronic acid and collagen, it can be observed that lower levels lead to more wrinkles as we age. The logical consequence: We must manage to increase the collagen concentration againWe have already seen one way.
With sufficient sun protection we can effectively protect our skin from harmful UV radiation. This alone is usually only a partial step – ideally we manage to stimulate collagen productionHowever, we cannot simply apply collagen to our skin. The molecule is far too large and would never pass through our skin barrier. Another route is through our gastrointestinal tract, where we can absorb collagen.
Did you know? The amino acid glycine is not only the ultimate for the skin. As a neurotransmitter, the molecule helps regulate nerve impulses and also promotes muscle growth. This amino acid has also aroused interest in aging research.
GlyNAC – the combination of glycine and N-acetyl cysteine – was able to stop aging in both humans and animals by supporting the production of glutathione – our body’s most important radical scavenger.
Low molecular vs. high molecular – a small but subtle difference
As already mentioned, collagen consists of very long, cord-like molecules. These can be found, for example, in some animal products, such as bone marrow, chicken skin or fish. These collagen molecules are broken down by stomach acid after absorption and split into their amino acids. What initially sounds disadvantageous is actually necessary. The individual amino acids can be absorbed into our body from the intestine – Collagen as a whole would not fit through our intestinal wall.
If you want to supplement collagen, this is preferably already cut into smaller pieces and additionally packed in a protein shell. Without this “preparation” it seems to have no effect.The studies on humans were carried out either with high molecular weight collagen, meaning there were large collagen chains in the protein shells, or with low molecular weight collagen. If you look at the studies more closely, low molecular weight collagen shows significantly better results.
The authors of this study also provide an explanation for this. The smaller molecules can be better absorbed by our intestines and thus reach the skin, where collagen synthesis is ultimately stimulatedWith larger molecules we have the problem that our intestines cannot fully absorb them and instead they are broken down.
Be careful when choosing the right collagen supplement. Studies have shown that low-molecular preparations are significantly more effective.
Collagen as an arthrosis killer – what’s the truth?
In addition to the skin, we find collagen in our joints and the tendonswith which our muscles attach to the bones. Here too, we see that collagen density decreases with ageOur joints hurt due to arthritic changes, the tendons can no longer bear the load as efficiently as in previous years and we become "stiffer" overall. Can collagen help here too?
To answer this question, we can imagine this meta-study look atA meta-study is a research project that brings together and evaluates as many studies as possible on the same question. This is an attempt to eliminate random results and get a little closer to the "truth".
The researchers found that a daily intake of 5-15g of collagen led to improved joint function and less painThe older the subjects were, the more they benefited from daily collagen intake to increase strength. In younger, fitter subjects, this effect was less pronounced, but could be increased with the addition of vitamin C.
Citrus fruits are an important natural source of vitamin C – an essential co-factor for the synthesis of collagen.
Here, the researchers found that vitamin C in combination with a Supplementation of collagen can increase production by fibroblastsThis makes sense if you can remember the complicated-sounding enzymes of collagen biosynthesis. Two of them require vitamin C as a co-factor.
A final, interesting fact that the scientists bring out in their meta-analysis is the effect of collagen on the recovery time of muscles after a workoutHere a small but measurable improvement during the time when the subjects took collagen.
Did you know? Have you ever heard of the brittle bone disease (osteogenesis imperfecta) This rare, genetic disease is caused by a disorder in collagen formation. There are 11 different forms of the disease.Depending on the severity of the disease, the fragility of the bones increases to such an extent that they literally shatter like glass.
Collagen types explained: Which type does what?
There are at least 16 different types of collagen, but most scientists focus on the first four main types: collagen types I, II, III and IV.
- Collagen type I: This is the most common type and is responsible for the health of skin, hair, nails, organs, bones and connective tissue. It is also the strongest collagen in the body and provides the structure for most tissues.
- Collagen type II: This type is found primarily in cartilage and plays an important role in building and maintaining healthy joints. It also helps reduce inflammation and relieve joint pain.
- Collagen type III: This collagen is found in large quantities in the skin and blood vessels and helps keep the skin firm and elastic. It often works hand in hand with type I.
- Collagen type IV: This type is essential for skin health and is found in the layers of the skin known as the basement membrane. It supports the functions of skin cells and promotes the formation of new cells.
Vegan Collagen Alternatives: Myth or Reality?
Collagen is an essential component of our body, but as an animal product it is not suitable for vegansHowever, there are vegan alternativesto promote your body's collagen production.
- Protein: Collagen is made from amino acids, so adequate protein intake is crucial for collagen production. Plant proteins, such as those found in legumes, whole grains, and nuts, can help provide the needed amino acids.
- Vitamin C: This vitamin plays a key role in collagen formation. It is abundant in many plant foods, including citrus fruits, berries, green leafy vegetables, and peppers.
- zinc and copper: These minerals are also important for collagen production. They are present in a variety of plant foods, including nuts and seeds, whole grains, and certain vegetables.
- Plant-based collagen boosters: There are also special supplements that aim to promote collagen production. These often contain a mixture of the above nutrients as well as other secondary plant substancesknown to support skin health.
With the Skin Glow Essentials Bundle you combine the power of all three molecules: hyaluronic acid, collagen and glycine for a skin-close synergy
Collagen in cosmetics: Is it still relevant?
Collagen is a popular ingredient in many skin care products and cosmetic treatments, as it is considered an essential building block for healthy skin, hair and nails.But is it really as effective as claimed?
Collagen in skin care products
The idea behind using collagen in skin care products is that it can help tighten the skin and reduce wrinklesby supplementing the body's natural collagen production. However, there are some doubts about the effectiveness of these products. Collagen molecules are too large, according to some expertsto effectively penetrate the skin and bring about changes at the cellular level.
Collagen in cosmetic treatments
There are various cosmetic treatments that aim to stimulate collagen production. This includes Microneedling, laser treatments and ultrasound therapy. A famous user of these methods is the American millionaire Bryan Johnson. These treatments can help rejuvenate the skin by stimulating collagen production and improving the appearance of wrinkles and fine lines.
Preventing collagen degradation – these are the options
Collagen is one of our most important structural proteins. However, as we age, the amount of collagen decreases, which leads to wrinkles and weaker tendons and joints. We have various options to prevent this breakdown. We can protect our skin from UV radiation and at the same time stimulate collagen biosynthesis by giving our body the necessary building blocks in the form of peptides.
One of the most effective methods to prevent collagen degradation is balanced diet. Foods rich in protein, vitamin C and other antioxidants can promote collagen production. In addition, certain supplements, such as our MOLEQLAR Collagen, help increase collagen levels in the body.
Another important factor in preventing collagen degradation is the protection against sun damage. UV rays can break down collagen in the skin and cause premature aging, so it's important to always use adequate sun protection when you're outdoors.
Last but not least, regular physical activity can also help prevent collagen degradation. Exercises that work the whole body, such as yoga or swimming, can improve blood circulation and thus help nutrients to be transported more efficiently to the skin cells, which in turn supports collagen production.
The devil is in the details. For collagen, low-molecular preparations such as MOLEQLAR Collagen, ideal, while hyaluronic acid for example, it is significantly more effective in its high molecular form. Together, hyaluronic acid and collagen form an effective duo for your structural health!
