What is regeNAD (NAD Regenerating Complex)?

NAD (nicotinamide adenine dinucleotide) is one of the most popular molecules in longevity research. This is no coincidence, as it has been proven many times that our NAD levels drop sharply with ageAt the same time, studies show that increasing NAD levels is associated with numerous positive effects on various aspects of our health. For longevity researchers such as David Sinclair or Mark Hyman NAD is the answer to key questions about aging. But how can we maintain our NAD levels and what role can regeNAD from MoleQlar play in this?

One way is to supplement precursor molecules and the other is to slow down the degradation. A third option is to support the NAD-producing enzymes. regeNAD from MOLEQLAR combines all three possibilitiesThe composition of the NAD Regenerating Complex is based on the latest scientific findings and well-researched molecular pathways.

NAD – why you want to keep your levels high as you age

Higher levels of NAD have produced impressive results in animal studies. On average, the animals studied not only lived significantly longer (between 10 and 20% depending on the study), but were also significantly fitter. Her insulin sensitivity and their memory performance was significantly better than in the control groups. The first studies on humans are also showing good results and many more clinical studies are underway. To help you better understand the biochemical background, we will briefly show you the most important points as an overview.

NAD metabolism – a brief overview

NAD metabolism is extremely complex and many molecules and enzymes play a role. Here is a brief summary of the most important points:

• NAD is constantly built up and broken down in our body
• There are three wayshow our body can produce NAD:
  • Preiss-Handler pathway (niacin)
  • Recycling Path (NMN, NR, Nam)
  • de novo pathway (tryptophan)
• The rate-limiting step (“bottleneck”) for the production of NAD is enabled by an enzyme called NAMPT – NMNAT is also very important
• As we age, the amount of NAD in our body decreases.
• The reasons for this are as follows:
  • The production is decreasing (fewer precursors, fewer enzymes)
  • The degradation or consumption increasesThis happens through various enzymes that become active as we age. One of them is called CD38.
• Higher inflammation levels increase CD38 activity and thereby lower NAD
• Researchers have found in numerous animal studies as well as in human trials that high NAD levels are associated with improved health in old age

For more background information, you can always visit our detailed articlesl on the NAD-Metabolism reading.

Boosting NAD – why precursors are not enough

High NAD levels seem to be a promising way to increase vitality in old age. The first logical step would be to use the finished molecule. This quickly proved to be not particularly effectiveNAD (whether intravenous or oral) is “too big” and cannot be directly absorbed by our cells.

Let’s take another look at NAD metabolism. Nicotinamide adenine dinucleotide is known to be produced in three different ways. All three decline with age, so we'll look at how we can strengthen each pathway.

On the "de novo pathway“ our body can, on the basis of various precursors, produce new NADThe only question that remains is which precursor? This question has not yet been fully answered. There are some human studies on NR (nicotinamide riboside) as a supplement. However, the results are mixed, as not all people experienced an increase in NAD, but rather some degradation products were increased. Another possibility is to provide more "material" for synthesis. Our body uses the amino acid L-tryptophan as the basis for the synthesis of new NADIf we increase the supply of this amino acid, we can support the “de novo pathway”.

Nicotinamide and nicotinic acid are two very similarly structured molecules. They only differ in one chemical group. Nicotinic acid, also abbreviated NA, contains a carboxyl group (COOH), while nicotinamide has a nitrogen-containing amide group. Both are derivatives of vitamin B3, also called niacinAlthough very similar in structure, the two molecules are metabolized slightly differently. Nicotinic acid is the starting material for the Preiss-Handler pathway. Here, NA is converted into NMN via the enzyme NAPRT.

nicotinamide can also be converted as a precursor to NMN. Interestingly, the molecule produced can be converted back to NAD not only via the "de novo pathway" but also via the "salvage pathway", which is the most active of the three pathways. Thus, we can strengthen all three paths.