Hyaluronic acid is known to many from plastic surgery, where the substance has long been used as a "wrinkle filler" for the skin. The molecule occurs naturally in our bodies. We can even produce it ourselves to a certain extent. However, the amount of hyaluronic acid in our bodies decreases with age, leading to reduced skin elasticity. Some studies have shown that regular hyaluronic acid supplementation can reduce the depth of wrinkles. Learn more here about the fascinating molecule hyaluronic acid and the benefits it offers you..
Occurrence of hyaluronic acid
The name hyaluronic acid comes from its discoverer, Karl Meyer. In the 1930s, he first isolated a substance from the vitreous humor of bovine eyes, a substance composed of many disaccharides and uronic acids. The ancient Greek word for glass is "hyalos," and thus he named the newly discovered substance. Hyaluronic acidHyaluronic acid is the abbreviation of the word.
Our bodies contain approximately 15 grams of hyaluronic acid, distributed among other places in our joints, connective tissue, the vitreous humor of the eye and in the skinApproximately half of the total hyaluronic acid is located in the skin, both in the upper epidermis and in the deeper dermis.
Here are a few more impressive figures:
– The hyaluronic acid content in the skin of a 75-year-old is approximately only a quarter compared to that of a 19-year-old person!
Your body synthesizes approximately 5g of hyaluronic acid per day, and the same amount is broken down again. So, roughly one-third of the total amount of hyaluronic acid in your body is broken down and rebuilt every day..
Hyaluronic acid (hyaluronan) is very frequently used in plastic surgery.
What does hyaluronic acid do?
To understand the role of hyaluronic acid in our bodies, we need to take a closer look at its molecular structure. Hyaluronic acid consists of a chain of disaccharides, also known as double sugars. These disaccharide molecules are modified glucose units, which bear the complex names D-glucuronic acid and N-acetyl-D-glucosamine. These modifications allow the individual disaccharides to be linked together like a chain. Chemically, this is called polymerization. This structure makes it possible for... that hyaluronic acid can bind a lot of water.
Depending on how many disaccharides are linked together, molecules of varying weights are obtained. A rough distinction is made between light, also low molecular weight hyaluronic acid (LMW) called, and severe, so-called high molecular weight hyaluronic acid (HMW).
This distinction is important because the two molecules have different properties.
High molecular weight hyaluronic acid (HMW)
Hyaluronic acid with a molecular weight of 10 or higher is considered high molecular weight.6 Dalton. That's approximately 100 kilodaltons (kDA). High-molecular-weight hyaluronic acid, as found in MOLEQLAR Hyaluron It occurs naturally in articular cartilage and synovial fluid, where it acts as a lubricant. Furthermore, several studies have shown that it has a positive effect on wound healing.It supports connective tissue and, through interaction with surface molecules of our immune cells, reduces inflammation in the body.
Furthermore, in some double-blind, placebo-controlled studies (highest level of evidence), it was demonstrated that after 28 days of oral intake of high molecular weight hyaluronic acid, the depth of wrinkles was significantly reduced.
One gram of hyaluronic acid can bind approximately 6 liters of water.The vitreous humor of our eye consists of approximately 98% water. The remaining two percent is hyaluronic acid and collagen fibers.
Low molecular weight hyaluronic acid (LMW)
Low molecular weight hyaluronic acid was also able to reduce wrinkle depth in some studies – however, it was not as effective as high molecular weight hyaluronic acid. Pro-inflammatory signals were more likely to be observed with low molecular weight hyaluronic acid..
In certain diseases, such as bronchial asthma, pulmonary fibrosis, and arterial hypertension, the body's own high-molecular-weight hyaluronic acid is converted into low-molecular-weight hyaluronic acid. Studies have shown that this shift towards more low-molecular-weight hyaluronic acid promotes an increased inflammatory response.
Hyaluronic acid in science and research
Hyaluronic acid is used in many areas of medicine due to its unique biological and chemical properties. Here are some examples:
- as a "carrier substance" in pharmaceuticals.
- as a topical application in wound healing
- in eye surgery, to protect the eye
- as a "lubricant" in the joint
- as an ingredient in nasal sprays to reduce dryness
There are many other areas where hyaluronic acid is used. One research area, for example, is the use of hyaluronic acid as a "carrier" molecule for cancer drugs. It has been shown that some tumors overexpress the CD44 receptor. Hyaluronic acid can bind to this receptor, making it an interesting molecule for developing targeted therapies.
Did you know?
The Hyaluronic acid is a very versatile molecule that plays an important role in aging research. It likely has an effect on positively impacted some of the Hallmarks of Aging out of. This is one of the reasons why we are in our innovative MoleQlar ONE also rely on hyaluronic acid as an effective ingredient.
Due to its water-binding capacity, hyaluronic acid is an ideal lubricant in our joints.
How do we absorb hyaluronic acid?
Hyaluronic acid, as mentioned earlier, is a rather large molecule. Too large to be fully absorbed by our intestines. For this reason, it was long assumed that swallowing hyaluronic acid supplements was ineffective, since the molecule is broken down into smaller pieces in our intestines.
This assumption, however, has been disproven. While hyaluronic acid is indeed broken down into smaller fragments in our intestines, these fragments find their way into our connective tissue and activate the same signaling pathways there as hyaluronic acid itself. Additionally, high molecular weight hyaluronic acid is absorbed as a complete molecule via our lymphatic system. A larger review compiled the results of several studies.Several results emerged. First, the researchers found that after at least four weeks of daily intake of high-molecular-weight hyaluronic acid, wrinkles were reduced and skin hydration improved. Even more exciting is a study that demonstrated that orally ingested high-molecular-weight hyaluronic acid is incorporated into the connective tissue pathway.
In one study Sixty patients with osteoarthritis of the knee were given 200 mg of hyaluronic acid orally for 12 months. The other group received cornstarch. Both groups participated in a comparable exercise program. After 12 months, the hyaluronic acid group showed improvement. It showed a greater reduction in pain, with those under 70 years of age particularly benefiting from daily intake..
Hyaluronic acid typically has a very viscous consistency in skincare products.
Hyaluronic acid in the cosmetics industry
Hyaluronic acid has long been known in the cosmetics industry as an additive in creams, serums or gels.
Our skin owes its elasticity and firmness to connective tissue. Its main components are: Collagen, elastin and hyaluronic acidDue to its water-binding ability, hyaluronic acid is responsible for the moisture content and thus indirectly for the firmness of our skin.
As our bodies produce less hyaluronic acid with age, causing the skin to lose moisture, this filling substance is lost. We see this when our skin develops wrinkles. Often, our skin reflects how old we feel. Our largest organ is visible to everyone around us, which is why we want to avoid skin aging as much as possible.
Hyaluronic acid gels promise to compensate for this fluid loss. However, the research on this is inconclusive. It is very likely that hyaluronic acid applied to the skin cannot penetrate deep enough into the skin.It tends to bind water to the skin. The only other option besides oral supplementation is hyaluronic acid injections. Depending on the type of hyaluronic acid used, the effect lasts from 6 to 24 months.
Collagen Collagen is the most abundant protein in our skin. Similar to hyaluronic acid, our bodies reduce collagen synthesis as we age. This also contributes to skin aging.
Glycine, an amino acidAccording to some studies, , which we ingest through food, can promote collagen synthesis and thus, together with hyaluronic acid, prevent premature skin aging.
Glycine and hyaluronic acid together therefore act on two important aging processes in the skin and can have positive effects on your skin health. Both molecules occur together in MOLEQLAR Hyaluron before. Furthermore, glycine is also available as pure Glycine powder available.
With the Skin Glow Essentials Bundle, you combine the power of all three molecules: hyaluronic acid, Collagen and glycine for a skin-close synergy.
Hyaluronic acid for different skin types: What you should know
There are different types of hyaluronic acid products that are tailored to different skin types.
Dry skin: Hyaluronic acid can help lock in moisture to relieve dryness and tightness. It is particularly effective when applied to damp skin and sealed with a moisturizing cream.
Oily skin: Even people with oily skin can benefit from hyaluronic acid, as it provides moisture without clogging pores or leaving an oily film on the skin.
Sensitive skin: Hyaluronic acid is very gentle on the skin and can therefore also be used on sensitive skin. It can help strengthen the skin barrier and minimize irritation.
“Old” skin: As we age, the skin's natural hyaluronic acid content decreases, which can lead to dryness and the formation of wrinkles. Hyaluronic acid products can help minimize these signs of skin aging.
Hyaluronic acid in skincare: this is the current state of science
Hyaluronic acid is a natural component of the body and is found in many skincare products. It is known for its ability to bind water, thereby hydrating and firming the skin.
Hyaluronic acid can bind moisture: Hyaluronic acid has the ability to reach up to to bind 1000 times their own weight in waterThis makes it an excellent moisturizer and helps to keep the skin hydrated and plump.
Hyaluronic acid can strengthen the skin barrier: Due to its moisturizing properties, hyaluronic acid can help strengthen the skin barrier and thus contribute to healthy, resilient skin.
Hyaluronic acid can minimize signs of skin aging: As we age, the skin's natural hyaluronic acid content decreases, which can lead to dryness and wrinkles. Topical applications of hyaluronic acid can help reduce these signs of aging.
Hyaluronic acid is safe for most skin types: Hyaluronic acid is very gentle on the skin and is generally well tolerated, making it a good option for all skin types, including sensitive skin.
Hyaluronic acid is one of the most effective moisturizers. It can retain 1000 times its own weight in water.
Hyaluronic acid vs. other moisturizers: A comparison
Compared to other moisturizing ingredients Hyaluronic acid offers more intense and longer-lasting hydrationIt draws water into the skin and retains it there, helping to keep the skin plump and hydrated. Furthermore, hyaluronic acid is also very gentle on the skin and is generally well tolerated, making it a good option for all skin types.
Other commonly used moisturizing ingredients are Glycerin, urea, aloe vera and various oils. Glycerin is another highly hygroscopic ingredient that draws water into the skin and helps retain it. Urea is known for its ability to smooth the skin and remove dead skin cells while simultaneously moisturizing.
Aloe vera is known for its soothing and moisturizing properties and can be particularly beneficial for dry or irritated skin. Oils, such as jojoba oil or argan oil, can also provide moisture. and thereby help to strengthen the skin barrier.
How to integrate hyaluronic acid into your daily skincare routine
Hyaluronic acid is a powerful moisture-binding agent and can easily be incorporated into your daily skincare routine.
Cleanse your face thoroughly: Before applying hyaluronic acid, it's important to cleanse your face to remove excess oil and dirt. This allows for better absorption of the hyaluronic acid by the skin.
Apply to damp skin: Hyaluronic acid binds moisture and draws it into the skin. Therefore, it is best to apply hyaluronic acid to damp skin to maximize its moisturizing properties.
Seal with a moisturizer: After applying hyaluronic acid, you should always apply a moisturizing cream or lotion. This helps to lock in moisture and improve the effectiveness of the hyaluronic acid.
Regular use: For optimal results, you should use hyaluronic acid products regularly. Many experts recommend using them twice a day, once in the morning and once in the evening.
Combine with other ingredients: Hyaluronic acid can be combined well with other ingredients in your skincare routine. For example, the combination of Hyaluronic acid with Vitamin C help, to improve the brightness and radiance of the skin.
At MoleQlar, we offer pure, vegan hyaluronic acid in capsule form and of the highest quality.
Hyaluronic acid in food
Hyaluronic acid is found in both animal and plant-based foods. In animal-based foods, it is primarily found in cartilage tissue or in broths made from animal bones. Other sources include:
- Fish, such as mackerel or gilthead bream
- potatoes
- Green leafy vegetables
- bananas
- almonds
- Sweet potatoes
- Cashew nuts
- tofu
The exact amounts of hyaluronic acid in foods are not well researched. A healthy, balanced diet, in addition to sufficient supplementation, can contribute to an increased intake of hyaluronic acid.
Hyaluronic acid and L-glycine form a skin-close synergy in the MoleQlar product.
How is hyaluronic acid produced?
Previously, hyaluronic acid had to be extracted from cow eyes or rooster combs in a laborious process. Since this method is not very sustainable, researchers have devised alternative methods.
Nowadays, hyaluronic acid is produced using genetically modified bacteria. Pure, vegan hyaluronic acid can be obtained in large fermentation plants. Through various filtration processes, the The risk of allergies is also lower than with animal products..The final product is also completely GMO-free, because the bacteria are completely removed.
This pure, vegan form of hyaluronic acid can you also with us Order now. Together with glycine, hyaluronic acid fights on the front lines of your metabolic and skin health!
Summary
Hyaluronic acid is an important component of our bodies. However, as we age, we gradually lose the ability to produce it. This leads to decreased skin elasticity, increased wrinkles, and less of the "lubricant" in our joints, resulting in more pain.
The Hyaluronic acid supplementation Hyaluronic acid has been rated as safe in numerous studies. Daily intake of hyaluronic acid can help reduce wrinkles and inflammation in the body. This, among other things, helps protect your largest organ, the skin, from premature aging.
