Every day, our body breaks down the food we eat into its molecular components. This enables us to utilize the fats, carbohydrates and proteins. But all the secondary plant substances, minerals, vitamins and micronutrients also find their way into our body via the intestines. How exactly this works is complicated in detail. There are various absorption pathways to ensure that all molecules reach their site of action.
So that you know better in future why, for example, the bioavailability of magnesium varies between 4 and 80%, why we should add certain secondary plant substances oil, what bioavailability actually is and what absorption pathways actually exist in our body, this article will tell you.
Absorption pathways - it all starts in the stomach
To give you a better idea of the different absorption pathways, let's look at an example together. Let's say you eat an apple. In your mouth, it is already chopped up and mixed with the first digestive enzymes. Generally speaking, digestive enzymes are helpers that can break down food into smaller pieces. The amylase can z.B. cut the long-chain carbohydrate chains into shorter pieces.
But back to our apple. It now ends up chopped up in an acid bath - the stomach. In this harsh environment, as many germs as possible should be destroyed by the acid and the food further softened. But this is not the only task of the stomach. It also produces the intrinsic factor (IF). This protein is essential for us to absorb vitamin B12. Without the intrinsic factor, this would hardly be possible.
200m2 Intestine for intake
After our apple has already been digested by the stomach acid, it now goes into the duodenum, where additional bile fluid and pancreatic juice meet the chyme. Pancreatic secretions contain peptidases that ensure that the proteins in our food are broken down into the individual amino acids.
Now that almost everything has been broken down, the crucial question remains. How can we absorb the remaining molecules?
The answer to this question is hidden in our small intestine. This is a fascinating evolutionary development. In an adult human, it is about 5m long and its surface area is more than 200m2, which is a little less than an entire tennis court.
On this huge surface there are a lot of transportersthat help us to absorb all the important components from our food. For example, our intestinal cells have a special transporter to absorb iron ions. We need these for the red pigment in our blood, haemoglobin. However, we can also absorb iron (in the form of haemoglobin) via the haem transporter, which is contained in meat.
First pass effect - the liver is in charge here
We have overcome the first hurdle. Our molecules have made the step from food, via the intestine, into our body. Via the portal vein - a vessel that collects all the blood from the digestive tract - they now reach the liver. It serves as the first detoxification site in the body.
All nutrients that have been absorbed via the intestine must first pass through the liver, where they are processed by the liver cells. The molecules are processed via various biochemical processes - and this has consequences for the further course of the disease. In medicine, this phenomenon is called the first pass effect.
Perhaps an example will help you to better understand the significance of the first pass effect. In medicine, various forms of opioidsare used. This class of drugs binds to the opioid receptors and thus provides strong pain relief. However, there is an opioid derivative that is not used for pain, but for diarrhea. Loperamide. This binds to the enterocytes (intestinal cells) in the intestine and thus ensures slower intestinal transit. However, like all other drugs, it also enters the bloodstream, where it is detoxified to over 99% in the liver and thus has hardly any effect in the rest of the body.
Parenteral, sublingual, buccal and co. - who is who?
Our liver is therefore a kind of upstream protective shield. Before a molecule reaches the brain or the heart, it has to pass the "entry check" in the liver. This makes perfect sense from an evolutionary point of view, but is sometimes a hindrance in medicine. This first pass effect can be partially circumvented by increasing the concentration of the starting substance so that the liver does not manage to "detoxify"all the molecules. However, this is often associated with some side effects.
In this case, it is somewhat more elegant to change the method of application. Instead of via the mouth, other parenteral (in addition to the intestine) absorption routes are available. If it has to be done quickly, buccal (via the buccal mucosa) or sublingual (under the tongue) administration of medication can be used. These are mainly painkillers that are dissolved in the mouth or under the tongue. These molecules are transported directly to the heartvia the blood vessels. The liver is thus bypassed. So that you can better understand the paths, we have provided you with a graphic.
This works in a very similar way with suppositories. The blood from the rectum no longer reaches the liver, but goes directly to the heart via the inferior vena cava. This is a popular method, especially in children, to channel active substances past the liver.
You are probably familiar with the last method from the hospital. We can also administer medication directly via the vein. This also bypasses the liver and the first-pass effect.
Liposomal vs. hydrophilic
We have now made it into the bloodstream, but there are still more hurdles to overcome. In principle, we can distinguish between molecules that are fat-soluble (lipophilic), such as vitamins A,D,E,K and water-soluble ones such as vitamin C. Water-soluble substances can be transported well in the blood, but have a harder time getting into the cells. The opposite is true for fat-soluble substances. In the blood, they often require special transport proteins, which makes it easier for them to pass through the phospholipid layer of the cells.
When we talk about blood lipid levels, these fat particles do not float around freely in the blood, but are bound to transport proteins such as apolipoprotein B. This means that these blood lipids can be made water-soluble. If you want to find out more about this and also which blood lipid levels are importantfor your longevity, please read our article on this
Bioavailability using the example of magnesium
Not everything we eat ends up in our blood in exactly the same way. Roughly simplified, you can imagine the bioavailability as follows. The concentration of the substance in the blood plasma (after it has passed through the liver) is measured and compared with the initial concentration. This can result in considerable differences.
A good example is magnesium. This occurs naturally in various compound forms, such as magnesium oxide, magnesium citrate or magnesium bisglycinate . The bioavailability of magnesium differs enormously between these compounds.
The well-known magnesium oxide has a bioavailability of just 4% ! This means that although this form is quite suitable for constipation, other forms are much more effective for supplementing magnesium. Magnesium citrate and Magnesium bisglycinate are both absorbed by our body by 80% , for example. Magnesium bisglycinate can also enter the brain via the blood-brain barrier.
Secondary plant compounds - the difficulty with bioavailability
Secondary plant compounds have a number of health benefits. We have already given you an overview in a separate article.
On the one hand, the problem with phytochemicals is their concentration. Large quantities of the pure substance are used in studies. To z.B. consume the amount of quercetin used there, we would need up to 100 apples - daily. For resveratrol there are, depending on the study 12l of red wine and with sulforaphane it would be up to 40kg of broccoli - all per day.
Some of the phytochemicals, such as resveratrol or quercetin, are fat-soluble. This makes it harder for us to absorb them for the reasons mentioned above and their bioavailability is low. To circumvent this, we can pack the molecules in a phospholipid layer and thus increase their bioavailability many times over.
With the blood sugar-lowering Berberine this formulation can increase bioavailability by 10-fold and for quercetin by 20-fold! This is made possible on the one hand by the combination of a lipid layer and on the other by the addition of adjuvants, i.e. molecules that can help with absorption. In the case of quercetin this is vitamin C and in the case of berberine a mineral complex.
Bioavailable berberine with chromium and zinc in the mineral complex Berbersome
Absorption of phytochemicals - the devil is in the detail
Not only quercetin and berberine need a little help to increase bioavailability, but also the sulforaphanecontained in broccoli. In green vegetables, this anti-inflammatory molecule is still present in its precursor, glucoraphanin . This is converted into sulforaphane in our intestines with the help of the enzyme myrosinase. However, the efficiency is not very high - it is about 10% and usually even lower, sincez.B . the individual substances are washed out by cooking for too long.
For this reason, Sulforapro contains both glucoraphanin and myrosinase. And there is another trick to ensure that the active ingredient arrives exactly where it is needed. In the intestine. The magic word here is: Gastro-resistant capsules.
Sulforaphane from molecular precursors combined with the finest broccoli extract - a natural source of sulforaphane
The right size is important
The molecules we consume every day all come in very different sizes. Some of them are too large to be absorbed directlyz.B. collagen and hyaluron , both important molecules for skin health. These substances form long molecular chains that cannot be absorbed by our body. So if we want to ingest collagen or hyaluronic acid through food, we have to pack the molecules into smaller packages, so-called peptide shells. These contain pieces of the original substance that have already been broken down. This is where it gets a little complicated.
In collagen the studies were able to show that it is advantageous if the fragments in the peptide shells are as small as possible. With Hyaluron it is exactly the opposite. Larger fragments, known as high molecular weight hyaluronan, have shown better results in human studies.
Conclusion on absorption pathways
The path from food to our cells is not always as simple as one might imagine. Fat-soluble and water-soluble molecules are absorbed differently. The liver metabolizes many molecules before they even enter the bloodstream, and the bioavailability of substances depends on their composition.
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