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What is collagen?

What is collagen?

Collagen is one of the most abundant proteins in our body.It makes up a large part of our connective tissue, which consists of long, fibrous molecules. Depending on its composition, collagen can have different properties. For example, collagen gives our skin structure, and collagen incorporated into tendons ensures greater tensile strength.

Collagen levels decrease with age.The consequences: Our skin becomes brittle and wrinkles, while our tendons are no longer as resilient as they once were. Here you can learn about the underlying causes and how you can partially halt this decline.

Collagen in our body: The structural basis

With a share of almost 30%, collagen is by far the most abundant protein in our body.It is produced by specialized cells called fibroblasts. Three amino acids are linked together to form long, fibrous molecules. The process always starts with... Glycine.

The long, thread-like molecules subsequently form a so-called Triple Helix They are interconnected. Imagine a braided plait; collagen structures look similar to that. Finally, these intertwined molecules initially accumulate. in smaller packages to form “fibrils” together, which in turn are then due to the large number of Collagen fibers form.

Did you know? Two important enzymes in collagen synthesis are prolyl hydroxylase and lysyl hydroxylase. Both need vitamin C as a cofactorWithout sufficient vitamin C, these enzymes cannot attach the important hydroxyl groups that are later necessary for the cross-links. Put simply, the resulting collagen would be significantly less stable.

Low molecular weight collagen peptides in powder form are one way to prevent the age-related decline in collagen levels.

The framework for healthy and firm skin

The collagen in our skin is constantly being regenerated by fibroblasts. The large collagen fibers serve as a kind of tight network., in which the various other molecules are arranged. Too much UV light and age lead to a lower collagen content over time. The result: Our skin wrinkles. But what causes this?

As always, there's no simple answer to a rather complex question. Researchers are aware of several factors. One of them is... UV radiation, which damages our skin in two waysFirstly, the activity of fibroblasts is inhibited, resulting in less new collagen production. Secondly, this leads to increased damage to the skin, which activates collagenases. These enzymes essentially "digest" functional collagen.

Furthermore, the composition of collagen fibers changes with age.They become thinner, making our structure increasingly brittle. The exact cause of this is not yet fully understood. One hypothesis is that blood supply, particularly through the tiny blood vessels, deteriorates with age, thus impairing collagen production.

Interestingly, UV damage appears to be independent of this.This means we already have an effective starting point for preventing premature skin aging: Regular application of a sunscreen containing UV protection (preferably SPF 50+) can effectively prevent skin aging..

Did you know? Next to Collagen Hyaluronic acid is extremely important for healthy skin and healthy joints. While collagen is water-insoluble and scores points primarily for its stability and firmness, hyaluronic acid binds exceptionally large amounts of water, thus providing volume.However, the hyaluronic acid content in our skin decreases with age, making it appear less "plump". Some studies have shown that oral supplementation with high molecular weight Hyaluron The wrinkle depth can be reduced. More information: what is Hyaluron?

Collagen and hyaluronic acid work together to improve skin elasticity and health in old age.

Fewer wrinkles thanks to collagen?

Both hyaluronic acid and collagen have been observed to have lower levels leading to more wrinkles with age. The logical consequence: We must manage to raise the collagen concentration again.We have already seen one way.

With adequate sun protection, we can effectively protect our skin from harmful UV radiation. However, this is usually only one step – Ideally, we will manage to stimulate collagen production.However, we can't simply apply collagen to our skin. The molecule is far too large and would never penetrate our skin barrier. Another route is through our gastrointestinal tract, where we can absorb collagen.

Did you know? The amino acid glycine isn't just fantastic for the skin. As a neurotransmitter, this molecule helps regulate nerve impulses and also promotes muscle growth. This amino acid has also attracted interest in aging research.

GlyNAC – the combination of Glycine and N-acetylcysteine ​​– was able to halt aging in both humans and animals by supporting the production of glutathione – the most important free radical scavenger in our body..

Low molecular weight vs. high molecular weight – a small but important difference

As mentioned earlier, collagen consists of very long, cord-like molecules. These can be found, for example, in… in some animal products, such as bone marrow, chicken skin, or fishThese collagen molecules are broken down by stomach acid after ingestion and split into their amino acids. While this might sound disadvantageous at first, it is actually necessary. The individual amino acids can then be absorbed from the intestines into our bodies. Collagen as a whole would not fit through our intestinal wall..

If you want Collagen supplementation, so this is preferably already broken into smaller pieces and additionally packaged in a protein coatingWithout this "preparation," it appears to have no effect. The studies on humans were conducted either with high-molecular-weight collagen, meaning that large collagen chains were contained in the protein shells, or with low-molecular-weight collagen. Looking at the studies more closely, low molecular weight Collagen significantly better results.

The authors of this study They also provide an explanation for this. The smaller molecules can be absorbed more easily by our intestines and thus reach the skin, where collagen synthesis is ultimately stimulated.With larger molecules, we have the problem that our intestines cannot fully absorb them and they are broken down instead.

Pay attention when choosing the right collagen supplement. Studies show that low-molecular-weight preparations are significantly more effective.

Collagen as an osteoarthritis killer – what's the truth?

Besides the skin, we find collagen in our joints and the tendons, with which our muscles attach to the bones. Here too, we see that collagen density decreases with age.Our joints hurt due to arthritic changes, our tendons can no longer bear the load as efficiently as in previous years, and we become generally stiffer. Can collagen also help in these cases?

To answer this question, can we imagine this Meta-study look atA meta-study is a research project that brings together and evaluates as many studies as possible on the same question. The aim is to eliminate chance findings and get closer to the "truth".

The researchers found that a Daily intake of 5-15g of collagen led to improved joint function and less pain.The older the participants were, the more they benefited from daily collagen intake to increase strength. This effect was less pronounced in younger, fitter participants, but could be improved with the addition of... Vitamin C be increased.

Mandarinen als natürliche Quelle für Vitamin C

Citrus fruits are an important natural source of vitamin C - an essential co-factor for the synthesis of collagen.

Here, the researchers discovered that vitamin C, in combination with a Collagen supplementation which can increase production by fibroblastsThis makes sense if you recall the complicated-sounding enzymes of collagen biosynthesis. Two of them require vitamin C as a cofactor.

One final, interesting fact that the scientists bring to light in their meta-analysis is the effect of collagen on the Recovery time of the Muscles after a training session. Here a small but measurable improvement during the time when the subjects Collagen peptides revenue.

Did you know? Have you ever heard of the Osteogenesis imperfecta (brittle bone disease) Have you heard of it? This rare genetic disorder is caused by a disruption in collagen production. There are 11 different forms of the disease. Depending on the severity, the bones become so brittle that they literally shatter like glass.

Collagen types explained: What does each type do?

There are at least 16 different types of collagen, but most scientists focus on the first four main types: collagen type I, II, III and IV.

  1. Collagen type I: This is the most common type and is responsible for the health of skin, hair, nails, organs, bones, and connective tissue. It is also the strongest collagen in the body and forms the structure for most tissues.
  2. Collagen type II: This type of hormone is primarily found in cartilage and plays an important role in building and maintaining healthy joints. It also helps reduce inflammation and relieve joint pain.
  3. Collagen type III: This collagen is found in large quantities in the skin and blood vessels and helps to keep the skin firm and elastic. It often works in conjunction with type I collagen.
  4. Collagen type IV: This type of cell is essential for healthy skin and is located in the layers of the skin known as the basement membrane. It supports the functions of skin cells and promotes the formation of new cells.

Vegan collagen alternatives: Myth or reality?

Collagen is an essential component of our body, but as an animal product it is Not suitable for vegansHowever, there are vegan alternatives, to promote the body's own collagen production.

  1. Protein: Collagen is made from amino acids, so adequate protein intake is crucial for collagen production. Plant-based proteins, such as those found in legumes, whole grains, and nuts, can help provide the necessary amino acids.
  2. Vitamin C: This vitamin plays a key role in collagen formation. It is abundant in many plant-based foods, including citrus fruits, berries, leafy green vegetables, and bell peppers.
  3. zinc and copper: These minerals are also important for collagen production. They are found in a variety of plant-based foods, including nuts and seeds, whole grains, and certain vegetables.
  4. Plant-based collagen boosters: There are also specific supplements designed to boost collagen production. These often contain a blend of the nutrients mentioned above, as well as others. secondary Plant substances, which are known to support skin health.

With the Skin Glow Essentials Bundle, you combine the power of all three molecules: hyaluronic acid, Collagen and glycine for a skin-close synergy

Collagen in cosmetics: Is that still relevant?

Collagen is a popular ingredient in many products. skincare products and cosmetic treatments, as it is considered an essential building block for healthy skin, hair and nails.But is it really as effective as claimed?

Collagen in skincare products

The idea behind using collagen in skincare products is that it can help to to tighten the skin and reduce wrinklesby supplementing the body's natural collagen production. However, there are some doubts about the effectiveness of these products. Because the According to some experts, collagen molecules are too large., in order to effectively penetrate the skin and bring about changes at the cellular level.

Collagen in cosmetic treatments

There are various cosmetic treatments that aim to... to stimulate collagen production. This includes Microneedling, laser treatments and ultrasound therapyA famous user of these methods is the American millionaire. Bryan JohnsonThese treatments can help rejuvenate the skin by stimulating collagen production and improving the appearance of wrinkles and fine lines.

Preventing collagen breakdown – these are the options available

Collagen is one of our most important structural proteins. However, the amount of collagen decreases with age, leading to wrinkles and weaker tendons and joints. We have various options to prevent this decline. We can protect our skin from UV radiation and simultaneously stimulate collagen biosynthesis by providing our body with the necessary building blocks in the form of peptides..

One of the most effective methods for preventing collagen breakdown is a balanced dietFoods rich in protein, vitamin C, and other antioxidants can promote collagen production. In addition, certain supplements, such as ours, can also help. MOLEQLAR Collagen powder, help to increase collagen levels in the body.

Another important factor in preventing collagen degradation is the Protection from sun damageUV rays can break down collagen in the skin, leading to premature aging. Therefore, it is important to always use adequate sun protection when outdoors.

Finally, regular physical activity can also help prevent collagen breakdown. Exercises that engage the whole body, such as... Yoga or swimming, can improve blood circulation and thus help to transport nutrients more efficiently to the skin cells, which in turn supports collagen production.

The devil is in the details. For collagen, low-molecular-weight preparations, such as... MOLEQLAR Collagen powder, ideal, while Hyaluron For example, it is significantly more effective in its high-molecular-weight form. Together, hyaluronic acid and collagen form an effective duo for your structural health!

Sources

Literature

  • Khatri, Mishti et al. “The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review.” Amino acids vol. 53,10 (2021): 1493-1506. Link
  • Kim, Jemin et al. “Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study.” Journal of medicinal food vol. 25,12 (2022): 1146-1154. Link
  • Barati, Meisam et al. “Collagen supplementation for skin health: A mechanistic systematic review.” Journal of cosmetic dermatology vol. 19,11 (2020): 2820-2829. Link
  • Barati, Meisam et al. “Collagen supplementation for skin health: A mechanistic systematic review.” Journal of cosmetic dermatology vol. 19,11 (2020): 2820-2829. Link
  • Ricard-Blum, Sylvie. “The collagen family.” Cold Spring Harbor perspectives in biology vol. 3,1 a004978. 1 Jan. 2011, Link
  • Rustad, Andrea M et al. “Myths and media in oral collagen supplementation for the skin, nails, and hair: A review.” Journal of cosmetic dermatology vol. 21,2 (2022): 438-443. Link
  • Rittié, Laure, and Gary J Fisher. “Natural and sun-induced aging of human skin.” Cold Spring Harbor perspectives in medicine vol. 5,1 a015370. 5 Jan. 2015, Link
  • Podolsky, Michael J et al. “Age-dependent regulation of cell-mediated collagen turnover.” JCI insight vol. 5,10 e137519. 21 May. 2020, Link

Grafiken

The images were acquired under license from Canva.

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