What is regeNAD (NAD Regenerating Complex)?

NAD (nicotinamide adenine dinucleotide) is one of the most popular molecules in longevity research. This is no coincidence, as it has been proven many times that our NAD levels drop sharply with increasing age. At the same time, studies show that an increase in NAD levels is associated with numerous positive effects on various aspects of our health. For longevity researchers such as David Sinclair or Mark Hyman , NAD is the answer to key questions about ageing. But how can we maintain our NAD levels and what role can regeNAD from MoleQlar play in this?

Firstly, you can supplement precursor molecules and secondly, you can slow down degradation. A third option is to support the NAD-producing enzymes. regeNAD from MOLEQLAR combines all three possibilities. The composition of the NAD Regenerating Complex is based on the latest scientific findings and researched molecular pathways.

NAD - why you want to keep your level up in old age

Higher levels of NAD achieved impressive results in animal studies. The animals studied not only lived significantly longer on average (between 10 and 20%, depending on the study), but were also significantly fitter. Their insulin sensitivity and memory performance were significantly better than in the control groups. The first studies on humans are also already showing good results and many more clinical trials are underway. To help you better understand the biochemical background, here is a brief overview of the most important points.

NAD metabolism - a brief overview

NAD metabolism is extremely complex and many molecules and enzymes play a role. Here is a brief summary of the most important points:

• NAD is completely built up and broken down in our body
• There are three waysin which our body can produce NAD:
  • Price-handler pathway (niacin)
  • Recycling pathway (NMN, NR, Nam)
  • de novo pathway (tryptophan)
• The rate-determining step ("bottleneck") for the production of NAD is enabled by an enzyme called NAMPT - NMNAT is also very important
• As we age, the amount of NAD in our body decreases
• The reasons for this are as follows:
  • The production decreases (fewer precursors, fewer enzymes)
  • The degradation or consumption increases. This occurs through various enzymes that become active with age. One of them is called CD38.
• Higher inflammation levels increase the activity of CD38 and thereby reduce NAD
• Researchers have found in numerous animal studies as well as in human trials that high NAD levels were associated with improved health in old age

For more background knowledge, you can always read our detailed articlel on NADmetabolism.

NAD boosting - why pre-stages are not enough

High NAD levels appear to be a promising path to more vitality in old age. The first logical step would be to fall back on the finished molecule. This quickly turned out not to be particularly effective. NAD (whether intravenous or oral) is "too big" and cannot be directly absorbed by our cells.

Let's take another look at NAD metabolism. Nicotinamide adenine dinucleotide is known to be produced in three different ways. All three decline with age and so we are looking at how we can strengthen each pathway.

Our body can produce new NAD via the " de novo pathway" on the basis of various precursors. The only question that remains is which precursor? This question has not yet been fully answered. There are some human studies onnicotinamide riboside capsules as a supplement. The results here are mixed, as not all people experienced an increase in NAD, but in some cases degradation products were increased. Another possibility is to provide more "material" for synthesis. Our body uses the amino acid L-tryptophanas the basis for the synthesis of new NAD. If we increase the supply of this amino acid, we can support the "de novo pathway".

Nicotinamide and nicotinic acid are two very similar molecules. They only differ in one chemical group. Nicotinic acid, also abbreviated NA, contains a carboxyl group (COOH), while nicotinamide has a nitrogen-containing amide group. Both are derivatives of vitamin B3, also known as niacin. Although very similar in structure, the two molecules are metabolized somewhat differently. Nicotinic acid is the starting material for the "Preiss-Handler Pathway". Here NA is converted into NMN via the enzyme NAPRT.

Nicotinamide can also be converted to NMN as a precursor. Interestingly, the generated molecule can be converted back to NAD not only via the "de novo pathway", but also via the "salvage pathway", which is the most active of the three pathways. Thus, we can amplify all three pathways.