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Strengthen mitochondria - energy, health & longevity

Strengthen mitochondria - energy, health & longevity

Mitochondria Strengthening – why this is crucial for energy, health, and longevity: Our modern lifestyle, with stress, lack of exercise, and often unhealthy nutrition, daily burdens our body. Especially our mitochondria, the tiny power plants of every cell, suffer from this. They are essential for energy production, influence performance, and play a key role in the aging process. When their function declines, it often manifests as fatigue, low vitality, and increased susceptibility. The good news: There are scientifically proven ways to improve mitochondrial function and regenerate your cellular power plants. In this guide, you will learn how to sustainably strengthen your mitochondria.

What are mitochondria? An overview of the power plants of cells

Mitochondria are tiny but vital cell organelles that regenerate the molecule adenosine triphosphate (ATP) – the universal energy carrier of our cells. Without ATP, basic cell functions could not occur. Due to this central role, mitochondria are also referred to as the "power plants of cells." Particularly energy-hungry cells such as heart, muscle, or nerve cells therefore have significantly more mitochondria than other cell types. In a heart muscle cell, they make up about one third of the cell volume – your heart literally beats thanks to these small energy producers.

As we age, mitochondria change. Scientific studies show that damaged mitochondria can be associated with diseases such as Alzheimer's, diabetes, or cancer.Therefore, intensive research is being conducted on how this aging process can be slowed down or even partially reversed – for example, within the framework of so-called mitochondrial therapy. What you can do in your daily life to strengthen your mitochondria and support their function will be explained in the following sections.
Did you know? Mitochondria have their own DNA, known as mitochondrial DNA (mtDNA). This is circular and located inside the mitochondrion, contains only 37 genes in humans, and is inherited exclusively from the mother. In comparison: The DNA in the cell nucleus contains information for about 20,000–25,000 genes.
Mitochondrien, Kraftwerk der Zellen

The importance of mitochondria goes far beyond mere energy supply.They are involved in essential processes such as calcium storage, the synthesis of certain hormones and signaling molecules, as well as the regulation of programmed cell death (apoptosis). Optimal mitochondrial function is therefore crucial for the health of each individual cell – and thus for overall well-being. When mitochondria are weakened or their function is disturbed (referred to as mitochondrial dysfunction), this can manifest in nonspecific signs such as chronic fatigue, reduced performance, or concentration problems.

Mitochondria and Longevity – Influence on Aging and Cell Health

Mitochondria play a key role not only in daily energy supply but also in relation to longevity.Researchers refer to the so-called Mitochondrial Dysfunction as one of the “Hallmarks of Aging” – that is, as a characteristic feature of the aging process at the cellular level. To understand this connection, it is worthwhile to take a look at the process of energy production in the mitochondrion.

Here, the so-called cellular respiration takes place: a multi-step process in which nutrients are converted into energy. Through the electron transport chain – an interplay of five protein complexes – electrons are transported, ultimately enabling the formation of adenosine triphosphate (ATP). A central molecule in this process is NADH, which can donate two electrons. From this step, ATP, our universal energy carrier, as well as NAD+, the oxidized form of NADH, are produced.

High NAD+ levels indicate that a lot of NADH is successfully converted into ATP – a sign of active energy production. Additionally, NAD+ activates certain enzymes called Sirtuins, which have been linked in research to cellular protective mechanisms and healthy cell function in aging. As we age, NAD+ levels decrease, highlighting the connection between mitochondria, energy production, and the aging process.

How can I strengthen my mitochondria? Strategies for more cellular energy

Your mitochondria can be positively influenced by certain habits and environmental factors. Here are some of the most effective strategies that have been associated in studies with improved mitochondrial function and increased cellular energy.


With Sports &and Movement Boost Mitochondria

Regular exercise is one of the most frequently studied approaches in research to support mitochondrial function. Research findings show that physical activity stimulates the formation of new mitochondria in muscle cells – a process known as mitochondrial biogenesis. Interestingly, this effect occurs not only in muscles: Exercise can also promote mitochondrial biogenesis in the brain. Scientific studies discuss this mechanism in connection with cognitive performance and healthy cell function in aging.
Practical Tip: Try to move daily – for example, by taking at least 10,000 steps. Fixed walking times help to reliably achieve this goal in everyday life.

Nutrition for Healthy Mitochondria

A Longevity Diet can support mitochondrial function. In addition to an adequate supply of all essential nutrients, mitochondria require certain cofactors to function optimally. Relevant micronutrients include copper, zinc, selenium, as well as the vitamins C, A , and E. Scientific literature describes that coenzyme Q10 may play a role in mitochondrial energy production.

Furthermore, the body responds to certain dietary patterns such as intermittent fasting or moderate calorie reduction with metabolic processes that have been associated in studies with improved mitochondrial function.Examples of this are intermittent fasting or the fasting-mimicking diet developed by Valter Longo.
Practical tip: Focus on a plant-based diet rich in fruits, vegetables, whole grains, nuts, and high-quality protein sources. Supplement with targeted nutrients as needed to ensure optimal supply, and occasionally try intermittent fasting as a possible support for your cellular power plants.

Cold training to activate the mitochondria

Scientific studies suggest that cold exposure can increase mitochondrial activity. One mechanism involved is the increased expression of PGC-1α, a key protein for the formation of new mitochondria.Additionally, studies have observed that repeated cold applications can accelerate autophagy – the cellular recycling process. For anyone dealing with longevity strategies, cold training could therefore be interesting.
Practical Tip: Incorporate cold showers or occasional ice baths into your daily routine. Cryotherapy applications are also currently being intensively researched and could provide more insights into possible effects in the future.
By the way: The term cryopreservation describes the freezing of humans in the hope of being able to revive them in the future – a topic that, while having little to do with everyday cold training, definitely provides food for thought.


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Symptoms and possible connections of mitochondrial dysfunction

Scientific studies describe that impaired mitochondrial function can be associated with various, often nonspecific complaints.These include, among others:
  • persistent fatigue or exhaustion
  • reduced physical and mental performance
  • concentration and memory difficulties
  • muscle weakness or pain
  • increased susceptibility to infections
  • problems with temperature regulation
  • changes in metabolism
In the scientific literature, mitochondrial dysfunction is also discussed in connection with various health conditions, including metabolic disorders, neurodegenerative diseases, or cardiovascular diseases. These connections do not necessarily mean that mitochondrial dysfunction is the cause – however, they underscore the scientific interest in this topic.

Conclusion – Strengthening Mitochondria for More Energy and Health

Mitochondria are central to energy metabolism and influence numerous processes in your body. Through conscious choices in the areas of nutrition, exercise, and lifestyle, you can specifically support their function. Strategies such as regular physical activity, balanced nutrient supply, or targeted cold training are associated in research with improved mitochondrial function. By giving your cellular power plants the attention they deserve, you can set impulses for actively supporting your energy production, performance, and long-term health.

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Literatur:

  • Chung N, Park J, Lim K. The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue. J Exerc Nutrition Biochem. 2017 Jun 30;21(2):39-47. 
  • Lettieri-Barbato D, Cannata SM, Casagrande V, Ciriolo MR, Aquilano K. Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle. PLoS One. 2018 May 9;13(5):e0195912.
  • Rodríguez-Cano AM, Calzada-Mendoza CC, Estrada-Gutierrez G, Mendoza-Ortega JA, Perichart-Perera O. Nutrients, Mitochondrial Function, and Perinatal Health. Nutrients. 2020 Jul 21;12(7):2166. 
  • Steiner JL, Murphy EA, McClellan JL, Carmichael MD, Davis JM. Exercise training increases mitochondrial biogenesis in the brain. J Appl Physiol (1985). 2011 Oct;111(4):1066-71. 
  • Winifred W. Yau, Kiraely Adam Wong, Jin Zhou, Nivetha Kanakaram Thimmukonda, Yajun Wu, Boon-Huat Bay, Brijesh Kumar Singh, Paul Michael Yen. Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue. iScience, Volume 24, Issue 5, 2021.


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